TUSC2

TUSC2
Identifiers
Aliases	TUSC2, C3orf11, FUS1, PAP, PDAP2, tumor suppressor candidate 2, tumor suppressor 2, mitochondrial calcium regulator
External IDs	OMIM: 607052; MGI: 1931086; HomoloGene: 5264; GeneCards: TUSC2; OMA:TUSC2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,328,251 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,443,311 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; Brodmann area 9; ; pars compacta; ; pars reticulata; ; nucleus accumbens; ; Amygdala; ; lateral nuclear group of thalamus;
	Top expressed in
	right kidney; ; superior frontal gyrus; ; muscle of thigh; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; gastrula; ; proximal tubule; ; neural layer of retina; ; cerebellar cortex; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	mitochondrion;
Biological process	regulation of mitochondrial membrane potential; cell-cell signaling; cell cycle; chemokine (C-C motif) ligand 5 production; cell population proliferation; inflammatory response; negative regulation of interleukin-17 production; cell maturation; neutrophil-mediated killing of gram-negative bacterium; regulation of reactive oxygen species metabolic process; defense response to Gram-negative bacterium; interleukin-15 production; positive regulation of interleukin-10 production; phagocytosis; natural killer cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	11334
	80385
	ENSG00000114383
	ENSMUSG00000010054
	O75896
	Q9WVF8
	NM_007275
	NM_019742
	NP_009206
	NP_062716
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor suppressor candidate 2 is a protein that in humans is encoded by the TUSC2 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114383 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010054 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fischer WH, Schubert D (Jan 1997). "Characterization of a novel platelet-derived growth factor-associated protein". J Neurochem. 66 (5): 2213–6. doi:10.1046/j.1471-4159.1996.66052213.x. PMID 8780057.
^ Kondo M, Ji L, Kamibayashi C, Tomizawa Y, Randle D, Sekido Y, Yokota J, Kashuba V, Zabarovsky E, Kuzmin I, Lerman M, Roth J, Minna JD (Oct 2001). "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells". Oncogene. 20 (43): 6258–62. doi:10.1038/sj.onc.1204832. PMID 11593436.
^ "Entrez Gene: TUSC2 tumor suppressor candidate 2".

References

Further reading