TWF2

TWF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VAC, 2W0I
Identifiers
Aliases	TWF2, A6RP, A6r, PTK9L, MSTP011, twinfilin actin binding protein 2
External IDs	OMIM: 607433; MGI: 1346078; HomoloGene: 5272; GeneCards: TWF2; OMA:TWF2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,246,788 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	106,092,588 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; granulocyte; ; gastrocnemius muscle; ; monocyte; ; glutes; ; left ventricle; ; triceps brachii muscle; ; blood; ; mucosa of transverse colon;
	Top expressed in
	intercostal muscle; ; granulocyte; ; soleus muscle; ; vestibular sensory epithelium; ; interventricular septum; ; thoracic diaphragm; ; medial head of gastrocnemius muscle; ; masseter muscle; ; muscle of thigh; ; digastric muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin monomer binding; protein binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; ATP binding; protein kinase C binding; RNA binding; cadherin binding; actin filament binding;
Cellular component	cell projection; filopodium; growth cone; intracellular anatomical structure; stereocilium; perinuclear region of cytoplasm; extracellular exosome; cytoskeleton; lamellipodium; cytoplasm; myofibril; actin filament;
Biological process	cellular response to retinoic acid; regulation of actin cytoskeleton organization; negative regulation of actin filament polymerization; cellular response to growth factor stimulus; cell projection organization; positive regulation of neuron projection development; positive regulation of axon extension; positive regulation of lamellipodium assembly; regulation of microvillus length; sequestering of actin monomers; barbed-end actin filament capping; regulation of lamellipodium assembly; actin filament depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	11344
	23999
	ENSG00000247596
	ENSMUSG00000023277
	Q6IBS0
	Q9Z0P5
	NM_007284
	NM_011876
	NP_009215
	NP_036006
	Wikidata
View/Edit Human	View/Edit Mouse

Twinfilin-2 is a protein that in humans is encoded by the TWF2 gene.^[5]^[6]^[7]

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000247596 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023277 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rohwer A, Kittstein W, Marks F, Gschwendt M (Aug 1999). "Cloning, expression and characterization of an A6-related protein". Eur J Biochem. 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.
^ Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M, Lappalainen P (Sep 2003). "Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated". J Biol Chem. 278 (36): 34347–55. doi:10.1074/jbc.M303642200. PMID 12807912.
^ ^a ^b "Entrez Gene: TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila)".

Yamada S, Uchimura E, Ueda T, et al. (2007). "Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen". Biochem. Biophys. Res. Commun. 363 (4): 926–30. doi:10.1016/j.bbrc.2007.09.069. PMID 17910947.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000247596 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023277 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10406962-5] Rohwer A, Kittstein W, Marks F, Gschwendt M (Aug 1999). "Cloning, expression and characterization of an A6-related protein". Eur J Biochem. 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.

[pmid12807912-6] Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M, Lappalainen P (Sep 2003). "Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated". J Biol Chem. 278 (36): 34347–55. doi:10.1074/jbc.M303642200. PMID 12807912.

[entrez-7] "Entrez Gene: TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila)".

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References

Further reading