TWF2

TWF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VAC, 2W0I
Identifiers
Aliases	TWF2, A6RP, A6r, PTK9L, MSTP011, twinfilin actin binding protein 2
External IDs	OMIM: 607433; MGI: 1346078; HomoloGene: 5272; GeneCards: TWF2; OMA:TWF2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,246,788 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	106,092,588 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; monocyte; ; left ventricle; ; triceps brachii muscle; ; blood; ; stromal cell of endometrium; ; body of tongue; ; lymph node; ; spleen; ; prefrontal cortex;
	Top expressed in
	intercostal muscle; ; soleus muscle; ; interventricular septum; ; thoracic diaphragm; ; masseter muscle; ; digastric muscle; ; external carotid artery; ; endocardial cushion; ; quadriceps femoris muscle; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin monomer binding; protein binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; ATP binding; protein kinase C binding; RNA binding; cadherin binding; actin filament binding;
Cellular component	cell projection; filopodium; growth cone; intracellular anatomical structure; stereocilium; perinuclear region of cytoplasm; extracellular exosome; cytoskeleton; lamellipodium; cytoplasm; myofibril; actin filament;
Biological process	cellular response to retinoic acid; regulation of actin cytoskeleton organization; negative regulation of actin filament polymerization; cellular response to growth factor stimulus; cell projection organization; positive regulation of neuron projection development; positive regulation of axon extension; positive regulation of lamellipodium assembly; regulation of microvillus length; sequestering of actin monomers; barbed-end actin filament capping; regulation of lamellipodium assembly; actin filament depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	11344
	23999
	ENSG00000247596
	ENSMUSG00000023277
	Q6IBS0
	Q9Z0P5
	NM_007284
	NM_011876
	NP_009215
	NP_036006
	Wikidata
View/Edit Human	View/Edit Mouse

Twinfilin-2 is a protein that in humans is encoded by the TWF2 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000247596 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023277 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rohwer A, Kittstein W, Marks F, Gschwendt M (Aug 1999). "Cloning, expression and characterization of an A6-related protein". Eur J Biochem. 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.
^ Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M, Lappalainen P (Sep 2003). "Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated". J Biol Chem. 278 (36): 34347–55. doi:10.1074/jbc.M303642200. PMID 12807912.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila)".

References

Further reading