Talk:Acceptance (House)

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Alcohol and Vicodin?[edit]

I feel like there should be some mention of this; House is always said to be taking "Vicodin," rather than another brand of hydrocodone, and the pills he takes are oblong and not round. All Vicodin pills manufactured by Abbot Laboratories EXCEPT round "Vicoprofen" pills contain both hydrocodone and acetaminophen. Further, House is depicted as typically taking a high number (I don't know the number, but it seems usually like three to five) of pills, several times a day.

In this episode, House appears to drink about a half a bottle of Bacardi 151, which means he ingested a little more than a quarter of a liter of ethanol.... That, with such a large quantity of acetaminophen, is just about guaranteed to cause liver failure. It seems like a doctor, even one as unconventional and self-destructive as House, would know better than to drink that much booze in combination with the Vicodin. —Preceding unsigned comment added by (talk) 18:36, 19 October 2007 (UTC)

Liver Failure[edit]

N-acetylcysteine (normally a mucolytic) protects the liver from paracetamol/acetaminophen overdose and is commonly used as an antidote. So Greg House could either had taken nac before drinking, or could actually use acetaminophen-free pills (containing only the morphinic agonist). Given that writer receive medical advices from 3 doctors, I don't think they could miss the liver failure. On the other hand, probably the show maker are using Tic-Tac or whatever cheap candy is handy to represent the Vicodin pills, which could look like the hydrocodone/acetaminophen combo you mention, even if it wasn't their intention. (There aren't pharmacist advisors mentioned working on this show and the doctor probably don't pay attention to pills). Also hospital could produce the pills locally if it is cheaper that way, in which case they won't necessarily look like the commercial ones (and actually, there's an episode in the first season where House manage to find some pills that look like Viagra in order to fool a patient). DrYak (talk) 03:24, 25 February 2008 (UTC)

Chemistry confusion[edit]

"alcohol, which should bind to the methanol in the copier fluid and neutralize it." I don't know whether this was written by the author of this article or said on the show, but in either way that is not the case - methanol doesn't actually bind to ethanol (common booze), but it occupies the enzyme (alcohol dehydrogenase) that oxidises all the alkoholes in the system. Products of methanol oxidation are much more poisonous than products of ethanol oxidation, and that's what really causes methanol poisoning. —Preceding unsigned comment added by (talk) 16:10, 6 August 2008 (UTC)

I double this, read on Competitive_inhibition and update the article accordingly. Ilyak (talk) 20:25, 14 May 2009 (UTC)