Talk:Chromatography in blood processing

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Messages

Avani,

I have a few notes on the article. After reading I wasn't completely sure if the point of the process was to extract pure albumin, to purify blood, or to do both at the same time possibly. I think it might be clearer once you format the article into sections, but I think thats an important thing to make sure you note early in the article. Also, this might just be due to the fact that its a draft, but when you mention fractions I, II and III, it would be good to either link to Vivek's article on the Cohn Process or simply to quickly describe what they are. One last thing that peaked my curiousity was in the paragraph about integrating new and old methods, where the result was albumin with lower aluminum and faster processing time. I'm just curious about the aluminum because I personally did not know that blood contained aluminum and i think it would helpful to say why its important to remove it. Overall though, I think once the article is formatted it will be good. There seems to be a lot of good info in it and its an interesting topic.

Steve Lund 22:04, 7 December 2006 (UTC)[reply]

Hey Avz, I read the article; it sounds interesting and the content is strong, but I think that adding organization to it will definitely change how it comes off to the reader. There are times when in one paragraph you talk about things like draw-backs, innovations, and details of method. Going through the article and putting similar themes together under headings would help this. There are also no links to other articles so for someone with no previous knowledge of chromatography it would hard to learn from this piece. Also, sometimes the article sounds story-like instead of a factual encyclopedia article so maybe some wording can be changed to sound more stronger. It looks like there is plenty of information in the article, so changing some of this mechanical stuff should help. Good Job!

Priya Shoor 01:19, 8 December 2006 (UTC)[reply]

Hey Avani, your article has a whole bunch of good information. All you need to do is to organize the article wikipedia-style by maybe doing a summary at the top and then breaking your subject down in different sections below. With this organization, I think it’ll be easier to quickly look at your page and know what your article is about. You also used some sentences that made the article flow better in paragraph form, but may not be needed once you use the new organization. Good job on finding all the good information.

Wwc26 05:11, 8 December 2006 (UTC)[reply]

Hey Avani,

I agree your article has a bunch of good info. For the last three paragraphs, you list a couple steps for one specific process. I think you should make a table out of it just to make it more readable. I also edited the last three paragraphs of your article. If you refer to my article, all my references would be useful for yours and there is a kistler-nitschmann picture that I have that would be good for your article too.

User:Vivek216

here are the references: Surgenor, Douglas. Edwin J. Cohn and the Development of Protein Chemistry. Center for Blood Research.

Harris, James R. Blood Separation and Plasma Fractionation. Wiley-Liss. 1991

Birnie ,G.D. Subcellular components: Preparation and Fractionation. Butterworth. 1972.

Graham, J.M., Rickwood, D. Subcellular Fractionation, a Practical Approach. Oxford University Press. 1997.

Petz, L.D, Swisher S. Clinical Pactice of Transfusion Medicine. Churchill-Livingstone. 1989.

The picture of the kistler model in on my page. just copy it from it for your kistler part.

User:Vivek216

Avani,

I sent you a file on webmail with a bit of copyediting. I changed a bit from past to present tense so if you decide to use any of my edits make sure it flows with the rest. Also, I found two pictures of the structure of human serum albumin if you'd like. Theres Human Serum Albumin from the Protein Data Bank. I'm not sure if you can copy that however but theres another almost identical picture in Human Serum Albumin on this site. I didn't have any luck however finding any media dealing with equipment of blood processing chromatography. Hope this helps a little.

Steve Lund 03:34, 15 December 2006 (UTC)[reply]

Quality of the article

The quality of the article is ok; I'd say a bit above average. Obviously it could be improved with better references still, and a more fluid read-through. The mention of a specific location in a single country seems weird to me - should perhaps describe a few countries. Right now it seems as if a single author may have wanted to focus on that country? But anyway, this is not what I am really wanting to write about. Instead, what I think would be useful is a TABLE that compares how efficient the chromatography methods are, compared to the old Cohn process or other variants before chromatography. I know that chromatography is highly popular in analytical chemistry (just look at modern HLPC devices, ultra-HLPC or rather HPLC ... I always get the abbreviation wrong). So it would be useful if a summary could be given, as a table, for a particular year (ideally 2020, aka right in this year), how EFFICIENT these methods are, including disadvantages and advantages. Yes, the article mentions a bit of this, but it would be better to have a more systematic view about this topic at hand, in a TABLE layout, since this is simpler for visitors to quickly see it. This was also my use case - I wanted to learn how much other methods improved on the Cohn process, and if you compare the articles on wikipedia, the non-chromatography articles contain some numbers which the chromatography-based variants don't. 2A02:8388:1641:8380:3AD5:47FF:FE18:CC7F (talk) 15:14, 8 March 2020 (UTC)[reply]