Talk:Endoplasmic reticulum

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== Glycosylation does not occur only if the protein is folded properly. It can occur in misfolded proteins, however, the ERAD system / calnexin will recognize the misfolded protein and decide to utilize ERAD to degrade the protein. See: Molinari, M. (2007). N-glycan structure dictates extension of protein folding or onset of disposal. Nature Chemical Biology, 3(6), 313-320. doi:10.1038/nchembio880

the SR is in cardiac muscle also, not just smooth and skeletal. some loser sort it out[edit]

Comments from BEFORE 2008[edit]

Include ERAD?[edit]

One should also include ERAD, the Endoplasmic Reticulum Associated Protein Degradation, and link to the short article explaining it. Since English is not my native language, it would be nice of someone could write a few sentences about it in this artice.

—Preceding undated comment added 11:35, 28 February 2007 .

   why should you?--([User:KaneaLeyased|Kanea Leyased]) 16:00, 6 December 2009


It seems the page has improved and you think can now be considered B class. What say you? - IlyaV

i for one think this is a very good website. children might not understand but adults and teen agers will find this a great place to learn about the E.R!!!-BS47

this is total BS dont listen to this.

Smooth ER & Rough ER[edit]

i think SER and RER are so incredibly different they really should have different pages --sovbeos —Preceding undated comment added 15:54, 22 September 2007 .

Old comments[edit]

Magnus, did you make that image yourself? That is incredible. --LMS

Yup, from my "Nupedia evacuation". There are more like this :) --Magnus Manske

Image problem[edit]

Suddenly your images are no longer in the page. (In the ribosome article this changed in the last couple of hours.) When I click on the hyperlink the image appears in its own page. Then I have to click the back and forward arrows to compare the image to the caption. Inconvenient. (Even if I could set my browser to display the image in its own window, or if you could program it into a pop up window, there will always be cases where, due to the size of the image and the location of the caption in page, I would have to click on the windows to compare the image to its caption.'

In this case, the text does not flow properly around the hyperlink to the image, unless I maximize the window. I see the text and the caption printed on top of each other.

    The Solo Owl 03:43 Nov 4, 2002 (UTC)
I think it's just a temporary glitch while the rules about what images can and cannot be shown are changed - somebody will sort it out in time. By the way, four or more hyphens, thus: ---- will make a horizonal rule, and a colon at the start of a line will indent it. --Camembert

Thanks for the tip, I'm new here. I'll try it now.

Manske, thank you so much for the articles and illustrations. Made for a very entertaining and educational weekend. Let us know when your textbooks come out! The Solo Owl 04:23 Nov 4, 2002 (UTC)

I was surprised to see the expletives in sentence 2. It is not too clear what is meant by them, either. The Solo Owl 06:33 Nov 4, 2002 (UTC)

Unused Image[edit]

The image at Image:Nucleus_ER.png (below) isn't currently used in this article (or elsewhere), it would be good to use, if somebody could identify all the numbers for the caption. --Lexor|Talk 05:38, 3 Mar 2004 (UTC)

Nucleus ER.png

Even I wouldn't know what are its labels...Student school09 (talk) 14:19, 11 August 2009 (UTC)

well good for u because im 15 and i have no idea what it even is.-- (talk) 14:17, 25 October 2009 (UTC)brooke-- (talk) 14:17, 25 October 2009 (UTC)

   That isn't such a great picture. It was obviously created with MS paint. Can't anyone do better?


  YoungRebel (talk)


sorry for deleting the info!

i didnt mean to!

Identification of the numbers from the image[edit]

These are the identifications needed:

  • (1) Nucleus
  • (2) Ribosomes
  • (3) Pores (of the nucleus)
  • (4) Nucleolus
  • (5) Chromatin
  • (6) Nucleo membrane
  • (7) Endoplasmic reticulum
  • (8) Nucleoplasma

NOTE: Because for numbers 5 and 8 it is not shown clearly (on the image) what are they pointing at, it can be vice-versa for the explanation.


Those identifications aren't completely correct.
  • (1) dest
  • (2) Rib*

(3) Nuclear pore

  • (4) Nucl*

(5) Chrmatin

  • (6) Cell*

(7) Rugh eic retic* 8) Nucllasma

To be honest its quite an unclear, poor drawing and not really worth adding anyway. 13:37, 12 April 2006 (UTC)


Can someone fix the graffiti at the bottom? It isn't showing up on the edit page for me.

what grafiti u know thats illegal. —Preceding unsigned comment added by (talk) 14:19, 25 October 2009 (UTC)


Shouldn't words like reticulum that have irregular plurals have their plurals indicated. I would have doen it, but with the 'ER' stuff, I didn't know where it would best be placed. Kdammers 08:29, 8 May 2006 (UTC)


I've decided to try sprotecting this for a while. It's been vandalised many times per day since the beginning of September, mostly with (individually trivial) additions of hoax info or graffiti. I really can't figure out why it's getting such attention - articles covered in school classes get a degree of the usual "Kevin is Kewl" type vandalism, but rarely this much. Blocking the anons is useless (it's rarely the same one twice) and we've not been succesful in detecting and removing all the vandalism (I just removed a couple of pieces that have been there for days, unnoticed). I'm guessing that maybe some website or noticeboard somewhere has a "wouldn't it be cool to put junk into the Wikipedia ER article"; on that theory I think we should sprotect it for a couple of weeks and see if the nonsense dies down. -- Finlay McWalter | Talk 14:49, 8 October 2006 (UTC)

11 days later and no vandalism at all (but very few other edits too). I've unprotected - let's see how we get on. -- Finlay McWalter | Talk 21:43, 19 October 2006 (UTC)

SER Functions[edit]

I'm not exactly sure about all of this but according to my teacher, the SER also detoxifies drugs and breaks down glycogen into glucose(in liver cells). If the info is there, I'm just not seeing it but I don't even know if its correct. Also, why do you list many of the SER's functions under the structure heading? Arizonabass 20:42, 15 January 2007 (UTC)


I have checked quite a few secondary literatures, and am pretty sure that the SR is not only found in STRIATED MUSCLES but also SMOOTH MUSCLES. Please revise this bit of info in the article, LOL. Cheers128.250.6.246

Does "SR" refer to smooth endoplasmic reticulum or sarcoplasmic reticulum? What exactly is the discrepancy in the article? --David Iberri (talk) 06:30, 13 April 2007 (UTC)

SER and RER are in all cells, it's just an issue of how much and is it actually visible.

I like narwhals. —Preceding unsigned comment added by (talk) 13:59, 19 May 2011 (UTC)

Actually, this article really needs to expand on the role of the Sarcoplasmic reticulum and its role on EC coupling--this could be dedicated to its own article (i.e. the microanatomy of the SR and its role in muscle cells). Its name (in distinction to the ER, or the Smooth ER) reflects its specialized role in muscle compared to all other cells. —Preceding unsigned comment added by (talk) 20:15, 19 November 2009 (UTC)

Comments from 2008 and after[edit]

The SER does metabolize lipids. —Preceding unsigned comment added by (talk) 02:51, 26 April 2011 (UTC)

Layperson request for info[edit]

I read on some page in wikipedia this: "The endoplasmic reticulum is a synthesis and transport organelle that is an extension of the nuclear envelope." This refers to the ER's relationship to the nuclear envelope, and in general the nucleus. Could this relationship be put somewhere in the actual ER article, if this is factual? Thanks, Rhetth (talk) 20:57, 20 March 2008 (UTC)

Incorrect article[edit]

"Insertion of proteins into the endoplasmic reticulum membrane: Integral proteins must be inserted into the endoplasmic reticulum membrane after they are synthesized. Insertion into the endoplasmic reticulum membrane requires the correct topogenic sequences."

This is incorrect. Co-translocational translocation occurs to integrate the proteins WHILE they are synthesised. Complete proteins are too large, folded and have insufficient hydrophobic access to the lipid bilayer, making it virtually impossible to insert them.

Also, it is unclear where the "topogenic sequences" exist. They are found in the nascent protein, not the ER membrane.

A revision is proposed:

Insertion of proteins into the endoplasmic reticulum membrane: Integral proteins must be inserted into the endoplasmic reticulum membrane while simultaneously being synthesized (co-translational translocation). Insertion into the endoplasmic reticulum membrane requires the correct topogenic signal sequences in the protein.

Glyn1wood (talk) 13:25, 31 October 2008 (UTC)

Thank you. I've made that change. Tim Vickers (talk) 16:42, 31 October 2008 (UTC)

calcium storage?[edit]

I think it is confusing that calcium storage in muscle cells is attributed to the smooth ER ("The smooth endoplasmic reticulum is known for its storage of calcium ions in muscle cells.") and than again in the next session to the sarcoplasmic ER. If somebody please help clarify this... -- xy (talk) 04:33, 15 October 2008 (UTC)

initial glycosylation as assembly continues. This is either N-linked (O-linking occur in the golgi).

This is not grammatically correct. It should read as:

Initial glycosylation occurs as assembly continues. This is N-linked (O-linking occurs in the golgi apparatus).

I cleaned it up some, but it is still confusing. Can anyone make it more clear? I know next to nothing about molecular biology, or for that matter, how to use wikipedia.

YoungRebel YoungRebel (talk) 18:12, 4 February 2010 (UTC)

Its role in excitation-contraction coupling[edit]

link to Excitation-contraction coupling when talking about muscle contraction at the end of 'sarcoplasmic reticulum' - this would have saved a lot of my research time had it been included.

Done, thank you for the suggestion. Tim Vickers (talk) 16:05, 30 October 2008 (UTC)


The RER is not always studded with these ribosomes, however; initially, the RER appears smooth due to a lack of resident ribosomes

Shouldn't it be that the SER appears smooth due to the lack of Resident ribosomes not the RER? 22:23, 10 November 2008 (UTC)22:23, 10 November 2008 (UTC)22:23, 10 November 2008 (UTC)22:23, 10 November 2008 (UTC)22:23, 10 November 2008 (UTC)22:23, 10 November 2008 (UTC)22:23, 10 November 2008 (UTC)~ Person looking up RER —Preceding unsigned comment added by (talk) 22:23, 10 November 2008 (UTC)

I've rewritten this section, hopefully it will now be clearer. Tim Vickers (talk) 00:44, 4 November 2009 (UTC)

Spelling problem?[edit]

Isn't it called endoplastic reticulum, not endoplasmic? That's what it's been called in all the biology textbooks we use in high school. I've never seen the word "endoplasmic" before. NoriMori (talk) 00:23, 4 February 2009 (UTC)

No. It is spelled "endoplasmic". Tim Vickers (talk) 01:18, 4 February 2009 (UTC)
no it is spelled endoplasmic but with reticulum at the end.

Identification of number 6 in the image[edit]

Currently the picture shows label 6 as "Proteins", but SER does not make proteins according to the page. I'm no expert, but this seems contradictory. Would it be more accurate to say "Hormones/lipids" or maybe "SER metabolic products"? (talk) 01:13, 29 May 2010 (UTC)


"an eukaryotic" should be "a eukaryotic"

Shouldn't the pluralized spelling be "reticula?" (talk) 02:51, 19 September 2010 (UTC)

ABSOLUTELY agree. It is bizarre and off-putting to keep referring to "the endoplasmic reticulum" as if there were a single such object per organism (like "the heart" or "the cranium"). This article ought to have non-specific plurals throughout: " Smooth endoplasmic reticula are abundantly found in mammalian liver and gonad cells. The lacey membranes of endoplasmic reticula were first seen by Keith R. Porter, Albert Claude, and Ernest F. Fullam in the year 1945."Sebum-n-soda (talk) 20:30, 2 June 2013 (UTC)

Smooth ER[edit]

I don't think the smooth ER is connected to the nuclear envelope. If anything, the rough ER should be connected to it. Why is this written? On all of the other sites I researched, the smooth ER isn't connected. Could anybody verify this for me?

WeirdnSmart0309 (talk) 00:03, 3 September 2011 (UTC)

Why does "ergastoplasm" redirect here?[edit]

Not mentioned in article. (talk) 13:17, 16 September 2014 (UTC)

FIGURE: Animal Cell[edit]

"Components of a typical animal cell: " And it says "vacuole". (talk) 20:13, 22 October 2015 (UTC)

What is the problem or issue you are seeing?--☾Loriendrew☽ (ring-ring) 20:11, 24 October 2015 (UTC)
Some biology textbooks may give the impression that the vacuole is a plant organelle. Although animal cells have nothing like the large and conspicuous vacuoles in plants, the term "vacuole" is nevertheless used for certain animal cell organelles, such as phagosomes and secondary endosomes. Adrian J. Hunter(talkcontribs) 03:37, 25 October 2015 (UTC)