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See also: cocaethylene. The chemistry behind the formation of this and ethylphenidate is more or less identical. Fuzzform 08:35, 28 October 2007 (UTC)

Levo-Methylphenidate or Dextro-Methylphenidate?[edit]

Is ethylphenidate formed with alcohol and levomethylphenidate or is it formed with alcohol and dextromethylphenidate or both? If both does it form more readily with one or another? Is there levo- & dextro- ethylphenidate too? (talk) 05:20, 13 November 2008 (UTC)

"...whereas the biologically active eutomer d-TMP does not react with ethanol to any significant extent..." (talk) 09:44, 16 September 2009 (UTC)

See, [1], [2], [3], [4]. I haven't read these articles in depth yet.--Literaturegeek | T@1k? 02:19, 17 September 2009 (UTC)


The initials "TMP" are not defined. Though I assume it means threo-methylphenidate, someone who knows could clarify. (talk) 21:26, 14 December 2009 (UTC)

Eudysmic ratio?[edit]

I have read the article [4](J.o. Medicinal Chemistry, 2005, Vol. 48, No. 8, page 2876-2881) and the values which are used in the paper [4] differs from the one in the article. Also in the Article there is no d-TMP mentioned just the racemic mixture of Methylphenidate. Only for Ethylphenidate are there values for both diastereomers and the racemic mixture. In the table is also a comparison with cocaine which is quite interesting. — Preceding unsigned comment added by EfaceX (talkcontribs) 22:24, 14 January 2012 (UTC)

What is a "superior" eudysmic ratio? The article should say specifically whether it is large or small. Qemist (talk) 11:11, 30 November 2012 (UTC)


both compounds generalize at 10mg/kg, meaning 700mg dose of TEP for a 70kg adult male would be the same as one of TMP? doesn't 700mg sound a bit lethal?

No, this is not lethal. Ld50 is 190mg/kg (death in half the cases) — Preceding unsigned comment added by (talk) 20:48, 9 March 2012 (UTC)

10mg/kg is still an extreme dose. I have eaten 50mg (0.7mg/kg) and it was very very strong. I don't recommend anyone even that much. You need to clarify that 10mg/kg is not a normal dose. For example Ritalin comes in 5 mg, 10 mg tablets. 70 times less. Stephan823 (talk) 22:22, 15 March 2012 (UTC)

I have removed this because it is potentially misleading and dangerous:

TEP is less stimulatory than TMP at 5mg/kg, although both compounds generalize at 10mg/kg. This is suggestive of a noradrenergic stimulatory effect present for TMP at lower doses.

If you want to return it to article then add information that it is not the dosage. Stephan823 (talk) 22:42, 15 March 2012 (UTC)

Analogue of Ketamine?[edit]

How could ethylphenidate be considered an analogue of ketamine under Australian law? They have vaguely similar structures, but they're significantly different structurally and completely different pharmacologically. — Preceding unsigned comment added by Exercisephys (talkcontribs) 04:34, 9 January 2013 (UTC)

Table units[edit]

The table does not have any units listed. This is confusing and poor form. Testem (talk) 21:10, 21 October 2013 (UTC)

Current UK legality[edit]

A TCDO does not put the drug in class B under UK law but in a sort of class D - it is illegal to sell or import but not illegal to possess[1], though if the police do find it in your possession they are allowed to confiscate it and have it destroyed. This is distinct from class A, B and C in UK law which also penalise possession. It is likely that 1 year from the original ban date it will transition to class A, B or C [2]. Page text need updating? (talk) 22:48, 24 July 2015 (UTC)

Original research/opinion[edit]

The half-life mentioned in the drug infobox isn't cited and is based on 'subjective reports' - I've removed this for now.

The article lede also contains a section about urban legends about the drug, but without citing any sources. Henry Stanley (talk) 23:14, 2 June 2017 (UTC)