Talk:Gentamicin

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Gentamicin.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Text and/or other creative content from Gentamicin toxicity was copied or moved into gentamicin with this edit. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted as long as the latter page exists.

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Rg cp133 g12, Khanhkdk12, Mnho cp133 g12, Lena Truong G12. Peer reviewers: 11kimbobese, Ttrannn 11, Echung11.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:13, 16 January 2022 (UTC)[reply]

Topical inclusion

Gentamicin can also be used topically, but this use is not mentioned in the article. — Preceding unsigned comment added by Niqueco (talk • contribs) 00:33, 21 August 2005 (UTC)[reply]

Done. Should I take out the sign? I only added two words... 84.42.146.44 03:12, 1 September 2005 (UTC)[reply]

i think somone should remove the link for "wobblers anonymous" from the side effects, and possibly put it into another paragraph - i rekon it is out of context in that part of the article —Preceding unsigned comment added by 80.192.146.160 (talk) 16:27, 24 June 2008 (UTC)[reply]

Would this Wiki be an appropriate place to comment on the reason this drug is spelled "-mIcin" instead of "-mYcin" as is the case with many other antibiotics, including the other aminoglycoside agents? I realize this is somewhat trivial, but this is often a source of frustration when clinicians try to search for "gentamycin" and are not successful because they don't realize that this is not the correct spelling. (I actually don't the reason for the naming convention and was hoping to find an explanation here.) Thanks for your consideration. --71.123.231.198 (talk) 03:33, 31 July 2008 (UTC)[reply]

It's more likely than not a name, rather than a naming convention for a class of antibiotics. There are other 'mycins' (macrolides for example) out there that aren't aminoglycosides. The only thing in common is that they are all derived from Streptomyces species. --Nikbro (talk) 01:24, 13 November 2008 (UTC)[reply]

Merger proposal

I've proposed that the page Gentamicin toxicity be merged into the "side effects" section of this page. Any discussion? Agathman (talk) 22:21, 13 April 2009 (UTC)[reply]

do it Mba123 (talk) 19:06, 17 May 2009 (UTC)[reply]

good idea!

--Kischel (talk) 13:58, 4 August 2009 (UTC)[reply]

Definitely, ASAP. --Cpt ricard (talk) 18:56, 28 November 2009 (UTC)[reply]

I've merged the two, and now for some clean-up --Cpt ricard (talk) 19:18, 28 November 2009 (UTC)[reply]

Disappointed

While this page isn't terrible, particularly by general wiki standards, compared to most other medications on here this page is really lacking. The side effects take up more than half of the article! I might be able to make some additions at some point, but it is definately in need of some work.McPat (talk) 13:40, 7 July 2009 (UTC)[reply]

Deafness

The article does mention "ototoxic", but it would be good to use language known to the layman, such as "deaf". —Preceding unsigned comment added by 134.134.139.72 (talk) 20:06, 20 December 2010 (UTC)[reply]

Wrong structure

The schematic structure given at the top is missing a N-methyl substitution (compare it with the ball and stick model which is correct). The C6-N is a secondary amine. It is the amine to the right in the schematic structure. Would someone be able to fix this? Silasmellor (talk) 11:20, 18 June 2011 (UTC)[reply]

Someone should fix the structures. But looking up the CAS registry number here, it says that it is actually not a pure substance but a mixture of 3 similar compounds, and that's also mentioned on ChemIDplus. Icek (talk) 12:30, 20 September 2013 (UTC)[reply]

Gentamicin inner ear side effects caused by drops to the eye?

Apologies if this not the appropriate place to ask this question, but the first paragraph of the side effects section deals extensively with side effects to the inner ear, yet the last sentence reads "these side effects are most common when the drug is administered via drops directly to the eye"; should that not read "these side effects are most common when the drug is administered via drops directly to the ear"? Oreeric (talk) 02:44, 3 July 2012 (UTC)[reply]

Relevance as a Cystic Fibrosis Treatment?

Can someone contribute a section on Gentamicin's possible use as a treatment for some variants of Cystic Fibrosis (and one for Duchenne Muscular Dystrophy too)? I lack the knowledge and expertise to do so :( AncientBrit (talk) 04:19, 22 December 2012 (UTC)[reply]

Orientation of the two structure diagrams

I'm an interested lay-person and often have trouble matching the chemical structure pic with the ball-picture. In this case it seems the one is the mirror (mirrored on a vertical axis) of the other. Can someone fix this? And is it too much to ask if someone who is a bit more proficient editing wikipedia to do this for any other pages they might come across? I'm sure I'm not the only one for whom this is an admittedly minor problem. Thanks, j.appelzaad 15:56, 13 March 2014 UTC — Preceding unsigned comment added by 87.211.115.30 (talk)

CP133 Focus Edits

We focused on adding a contraindications and special populations section to the page. These are important points regarding the medication, and it is good knowledge to know in which people it can be used safely or not. It is also a helpful guide for professionals in the healthcare field to know when not to use gentamicin. Our main focus for this paper included organizing it a little better and providing more information that we deemed useful to the general public. Rg cp133 g12 (talk) 04:15, 5 November 2015 (UTC)

Overall, for most of the sections, our group focused on the references and tried to add/strengthen the resources used by previous editors. We selected three areas: introduction, medical uses, and side effects and went through each sentence to make sure they all have good references attached to them. Additionally, we also added sections such as contraindication and special populations because we thought the public would find those information beneficialRg cp133 g12 (talk) 04:26, 5 November 2015 (UTC) — Preceding unsigned comment added by Rg cp133 g12 (talk • contribs)

CP133 Peer Review

Yes, this draft submission reflects a neutral point of view and points included were verifiable with cited published material. Some areas of improvement include:

Introduction: Try to include some common side effects along with serious side effects.
Side effects: Try adding specific information such as percentages if available regarding how likely the side effects will occur (similar to nephrotoxicity and ototoxicity).
Side effect – nephrotoxicity: Listing symptoms of kidney damage that patients can easily distinguish at home would be helpful.
Contraindications: List out a few examples of the type of hypersensitivity or the serious toxic reaction to look for.

Echung11 (talk) 06:05, 9 November 2015 (UTC)[reply]

This draft is unbiased, neutral, and well written with a lot of cited published sources. Recommendations for improvement:

maybe also use bullet appoints for the other "less common" side effects and how frequent the incidence is
maybe add use in hepatic/renal impairment

11kimbobese (talk) 07:29, 9 November 2015 (UTC)[reply]

1. Yes, this draft submission reflects a neutral point of view. 2. Yes, the points included in the article are verifiable with cited published material. 3. Some possible recommendations I would suggest to further improve this article include:

In contraindications, are nausea and vomiting considered a hypersensitivity that merits contraindication or are the more serious reactions such as low blood counts, allergic responses, neuropathy, or ototoxicity with prior gentamicin use considered instead? Are there guidelines to alternative antibiotics?
In special populations, I would include that although not recommended, gentamicin can, in fact, be used for life-threatening situations in both pregnant women and infants per package insert (pg 3).
Incomplete citations for History and Research sections
Multiple duplications in References section
Minor formatting with hyperlinked words being capitalized mid-sentence

Ttrannn 11 (talk) 09:53, 9 November 2015 (UTC)[reply]

External links modified

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External links modified (January 2018)

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Neisseria and Legionella error

The following statement is incorrect:

Gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the person going into shock from lipid A endotoxin found in certain Gram-negative organisms).

Gentamicin has not historically been used because these organisms are intracelluar and gentamicin penetration into cells is very poor. In fact gentamicin has been used successfully to treat drug-resistant gonorrhoea. I therefore propose deleting the bracketed word. Gak (talk) 17:01, 8 May 2018 (UTC)[reply]

Irreversible binding

I changed the irreversible binding to "irreversible" and it was reverted, but I believe that this was done in error. Aminoglycosides such as Gentamicin don't covalently bind to the ribosome so by the biochemical definition of reversible vs. irreversible inhibitors this would make gentamicin a reversible inhibitor. With that said, the reference in the area is from DrugBank, a very thorough and pretty reputable source, and even there it says irreversible in quotes. This is because while it doesn't covalently link to the ribosome, it's binding is very tight and seems irreversible as it kills bacteria. I'd recommend changing irreversible to reversible inhibitor via this reference which shows NMR structural studies on the binding of gentamicin.^[1]

Upon looking at common websites and searches there appears to be a lot of references to "irreversible" binding, but no biochemical studies are referenced, only drug databases. I am inclined to think that these are inaccurate based upon the mechanism of action of other aminoglycosides and also the quotation marks in the DrugBank.ca website. I won't change anything yet due to the conflicts online, but my recommendation would be to change it to reversible.

Therazzz (talk) 14:03, 18 March 2019 (UTC)[reply]

References

^ Yoshizawa, S. (16 November 1998). "Structural origins of gentamicin antibiotic action". The EMBO Journal. 17 (22): 6437–6448. doi:10.1093/emboj/17.22.6437.

Biosynthesis

Hi! I'm a chemist and I will be adding the biosynthesis of Gentamicin. I plan to discuss the mechanism, the unknown genes associated with the expressed proteins and the similarities to other aminoglycoside antibiotic biosynthesis in order too support the theories behind the unknown bits. I also planned to parse through the information already provided to ensure everything is up to-date in accordance with these sources:^[1]^[2]^[3]

I'm new to editing Wikipedia, So I'll probably post some questions here.

My first question is, are my sources ok for use on Wikipedia? I know I'm not supposed to use anything that is directly researched by the authors, I have a book and the other two sources are reviews.

Thanks everyone!! -- Cmlambert (talk) 04:35, 30 May 2021 (UTC)[reply]

Hello! I added my biosynthesis section and edited the introduction of the page to reflect the change. I also added a structure and fermentation section to support the biosynthesis information. Please let me know if there should be any corrections. Thank you! Happy editing. Cmlambert (talk) 09:47, 4 June 2021 (UTC)[reply]

References

^ Kumar, C.; Himabindu, M.; Jetty, Annapurna (January 2008). "Microbial Biosynthesis and Applications of Gentamicin: A Critical Appraisal". Critical Reviews in Biotechnology. 28 (3): 173–212. doi:10.1080/07388550802262197.
^ Yu, Yi; Zhang, Qi; Deng, Zixin (2017-05-18). "Parallel pathways in the biosynthesis of aminoglycoside antibiotics". F1000Research. 6: 723. doi:https://doi.org/10.12688/f1000research.11104.1. {{cite journal}}: Check |doi= value (help); External link in |doi= (help)
^ Dewick, Paul M. (2009). Medicinal natural products : a biosynthetic approach (3rd ed.). Chichester, West Sussex, United Kingdom. pp. 738–750. ISBN 978-0-470-74167-2.{{cite book}}: CS1 maint: location missing publisher (link)

[1] Yoshizawa, S. (16 November 1998). "Structural origins of gentamicin antibiotic action". The EMBO Journal. 17 (22): 6437–6448. doi:10.1093/emboj/17.22.6437.

[2] Kumar, C.; Himabindu, M.; Jetty, Annapurna (January 2008). "Microbial Biosynthesis and Applications of Gentamicin: A Critical Appraisal". Critical Reviews in Biotechnology. 28 (3): 173–212. doi:10.1080/07388550802262197.

[3] Yu, Yi; Zhang, Qi; Deng, Zixin (2017-05-18). "Parallel pathways in the biosynthesis of aminoglycoside antibiotics". F1000Research. 6: 723. doi:https://doi.org/10.12688/f1000research.11104.1. {{cite journal}}: Check |doi= value (help); External link in |doi= (help)

[4] Dewick, Paul M. (2009). Medicinal natural products : a biosynthetic approach (3rd ed.). Chichester, West Sussex, United Kingdom. pp. 738–750. ISBN 978-0-470-74167-2.{{cite book}}: CS1 maint: location missing publisher (link)

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