Talk:Hemolytic anemia

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This is a red hot subject in haematology: intravascular haemolysis causing pulmonary hypertension and related vascular complications: JFW | T@lk 07:30, 5 May 2008 (UTC)

Cool- the whole notion of NO interaction with hemoglobin in the RBC is a hot area, I wasn't aware that free hemoglobin would create a problem by this means, the iron is all I had read about. A simple search on terms turned up about 93 hits, too many for complete list. I'll post a few soon. Also of possible interest, hemoglobin or hemin or related things can ( protectively LOL) up regulate heme oxygenase in tubular epithelia cells, so things like hemoglobin may be net protective effects ( cites to follow maybe ...). Nerdseeksblonde (talk) 22:14, 16 November 2009 (UTC)
  • Chronic: I thought I could narrow it down to review articles on free hemoglobin toxicity with "fenton" but only returned once sickle-cell paper. I added chronic and got these 21 which may contrast with acute,

$ eutilsnew -v -xml -out xxx 'hemoglobin nitric oxide hemolysis chronic'

Boretti, FS; D'Agnillo, F; Kluge, K; Glaus, T; Butt, OI; Jia, Y; Goede, J; Pereira, CP; Maggiorini, M; Schoedon, G; Alayash, AI; Schaer, DJ (Aug-2009). "Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.". The Journal of clinical investigation. 119 (8): 2271–80. doi:10.1172/JCI39115. PMC 10.1172/JCI39115Freely accessible Check |pmc= value (help). PMID 19620788.  Check date values in: |date= (help)

Kato, GJ; Steinberg, MH; Gladwin, MT (Sep-2009). "Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions.". American journal of hematology. 84 (9): 618–25. doi:10.1002/ajh.21475. PMC 10.1002/ajh.21475Freely accessible Check |pmc= value (help). PMID 19610078.  Check date values in: |date= (help)

Conran, N; Costa, FF (2009). "Newer aspects of the pathophysiology of sickle cell disease vaso-occlusion.". Hemoglobin. 33 (1): 1–16. doi:10.1080/03630260802625709. PMC 10.1080/03630260802625709Freely accessible Check |pmc= value (help). PMID 19205968. 

Kato, GJ (10-Dec-2008). "Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy.". JAMA : the journal of the American Medical Association. 300 (22): 2638–46. doi:10.1001/jama.2008.598. PMC 10.1001/jama.2008.598Freely accessible Check |pmc= value (help). PMID 19066384.  Check date values in: |date= (help)

Piknova, B; Hogg, N; Schechter, AN (Mar-2009). "The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies.". Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. 20 (2): 88–94. doi:10.1016/j.niox.2008.10.005. PMC 10.1016/j.niox.2008.10.005Freely accessible Check |pmc= value (help). PMID 19010434.  Check date values in: |date= (help)

Wang, WC (Dec-2008). "The pharmacotherapy of sickle cell disease.". Expert opinion on pharmacotherapy. 9 (17): 3069–82. doi:10.1517/14656560802519878. PMC 10.1517/14656560802519878Freely accessible Check |pmc= value (help). PMID 19006479.  Check date values in: |date= (help)

Willmore, LJ (Apr-2009). "Posttraumatic epilepsy: hemorrhage, free radicals and the molecular regulation of glutamate.". Neurochemical research. 34 (4): 688–97. doi:10.1007/s11064-008-9841-3. PMC 10.1007/s11064-008-9841-3Freely accessible Check |pmc= value (help). PMID 18785008.  Check date values in: |date= (help)

Taylor, JG; Mendelsohn, L; Kato, GJ; Gladwin, MT; Steinberg, MH (2008). "Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain.". PloS one. 3 (5): e2095. doi:10.1371/journal.pone.0002095. PMC 10.1371/journal.pone.0002095Freely accessible Check |pmc= value (help). PMID 18461136. 

Kaul, DK; Dasgupta, T; Fabry, ME (Jul-2008). "Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress.". American journal of physiology. Heart and circulatory physiology. 295 (1): H39–47. doi:10.1152/ajpheart.00162.2008. PMC 10.1152/ajpheart.00162.2008Freely accessible Check |pmc= value (help). PMID 18456737.  Check date values in: |date= (help)

Wood, KC; Gladwin, MT (15-Apr-2008). "Sickle cell disease vasculopathy: a state of nitric oxide resistance.". Free radical biology & medicine. 44 (8): 1506–28. doi:10.1016/j.freeradbiomed.2008.01.008. PMC 10.1016/j.freeradbiomed.2008.01.008Freely accessible Check |pmc= value (help). PMID 18261470.  Check date values in: |date= (help)

Vichinsky, E (2007). "Hemoglobin e syndromes.". Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program: 79–83. doi:10.1182/asheducation-2007.1.79. PMC 10.1182/asheducation-2007.1.79Freely accessible Check |pmc= value (help). PMID 18024613. 

Dasgupta, T; Kaul, DK (15-Dec-2006). "Protective effect of arginine on oxidative stress in transgenic sickle mouse models.". Free radical biology & medicine. 41 (12): 1771–80. doi:10.1016/j.freeradbiomed.2006.08.025. PMC 10.1016/j.freeradbiomed.2006.08.025Freely accessible Check |pmc= value (help). PMID 17157180.  Check date values in: |date= (help)

Kato, GJ; Steinberg, MH (Jan-2007). "Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.". Blood reviews. 21 (1): 37–47. doi:10.1016/j.blre.2006.07.001. PMC 10.1016/j.blre.2006.07.001Freely accessible Check |pmc= value (help). PMID 17084951.  Check date values in: |date= (help)

Morris, Claudia (2006). "New Strategies for the Treatment of Pulmonary Hypertension in Sickle Cell Disease : The Rationale for Arginine Therapy.". Treatments in respiratory medicine. 5 (1): 31–45. PMID 16409014. 

Morris, CR; Kato, GJ; Lavrisha, L; Larkin, S; Singer, T; Vichinsky, EP (2005). "Hemolysis-associated pulmonary hypertension in thalassemia.". Annals of the New York Academy of Sciences. 1054: 481–5. doi:10.1196/annals.1345.058. PMC 10.1196/annals.1345.058Freely accessible Check |pmc= value (help). PMID 16339702. 

Machado, RF; Kato, GJ; Barst, RJ; Anthi, A; Robinson, MR; Hunter, L; Coles, W; Nichols, J; Hunter, C; Sachdev, V; Castro, O; Gladwin, MT (Aug-2005). "Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension.". British journal of haematology. 130 (3): 445–53. doi:10.1111/j.1365-2141.2005.05625.x. PMC 10.1111/j.1365-2141.2005.05625.xFreely accessible Check |pmc= value (help). PMID 16042696.  Check date values in: |date= (help)

Lin, EE; Gladwin, MT (Mar-2005). "Hemolytic anemia-associated pulmonary hypertension in sickle cell disease.". Current hematology reports. 4 (2): 117–25. PMID 15720960.  Check date values in: |date= (help)

Kaul, DK; Chang, HY; Nagel, RL; Fabry, ME (Oct-2004). "Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice.". The Journal of clinical investigation. 114 (8): 1136–45. doi:10.1172/JCI21633. PMC 10.1172/JCI21633Freely accessible Check |pmc= value (help). PMID 15489961.  Check date values in: |date= (help)

Korobov, VN; Korobova, OV; Datsiuk, LA. "[Small doses of X-ray irradiation activate the NO-synthase component of the nitric oxide cycle]". Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk. 43 (2): 182–5. PMID 12754805. 

Reiter, CD; Tanus-Santos, JE; Hogg, N; Cannon, RO; Schechter, AN; Gladwin, MT (Dec-2002). "Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.". Nature medicine. 8 (12): 1383–9. doi:10.1038/nm799. PMC 10.1038/nm799Freely accessible Check |pmc= value (help). PMID 12426562.  Check date values in: |date= (help)

Drummond, JC; Patel, PM; Reynolds, LW (Oct-1995). "Focal cerebral ischemia during anesthesia with etomidate, isoflurane, or thiopental: a comparison of the extent of cerebral injury.". Neurosurgery. 37 (4): 742–8; discussion 748–9. PMID 8559304.  Check date values in: |date= (help)

Nerdseeksblonde (talk) 22:18, 16 November 2009 (UTC)

Allosteric effect related to NO ( bit OT, but may be of interest elsewhere )[edit]

I didn't think I was making up that earlier comment but couldn't remember details. See Stepuro etal specifically and others here,

Jia, Y (Aug-2009). "Effects of cross-linking and zero-link polymerization on oxygen transport and redox chemistry of bovine hemoglobin.". Biochimica et biophysica acta. 1794 (8): 1234–42. doi:10.1016/j.bbapap.2009.04.008. PMC 10.1016/j.bbapap.2009.04.008Freely accessible Check |pmc= value (help). PMID 19409516.  Check date values in: |date= (help)

Gladwin, MT (1-Oct-2008). "The functional nitrite reductase activity of the heme-globins.". Blood. 112 (7): 2636–47. doi:10.1182/blood-2008-01-115261. PMC 10.1182/blood-2008-01-115261Freely accessible Check |pmc= value (help). PMID 18596228.  Check date values in: |date= (help)

Ronda, L; Abbruzzetti, S; Viappiani, C; Bettati, S (Oct-2008). "Ligand reactivity and allosteric regulation of hemoglobin-based oxygen carriers.". Biochimica et biophysica acta. 1784 (10): 1365–77. doi:10.1016/j.bbapap.2008.04.021. PMC 10.1016/j.bbapap.2008.04.021Freely accessible Check |pmc= value (help). PMID 18502214.  Check date values in: |date= (help)

Hellmann, N; Decker, H (2008). "Linked analysis of large cooperative, allosteric systems: the case of the giant HBL hemoglobins.". Methods in enzymology. 436: 463–85. doi:10.1016/S0076-6879(08)36026-1. PMC 10.1016/S0076-6879(08)36026-1Freely accessible Check |pmc= value (help). PMID 18237649. 

Stepuro, TL (Mar-2006). "Nitric oxide effect on the hemoglobin-oxygen affinity.". Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 57 (1): 29–38. PMID 16601313.  Check date values in: |date= (help)

Gow, AJ; Bonaventura, J (Apr-2005). "Invertebrate hemoglobins and nitric oxide: how heme pocket structure controls reactivity.". Journal of inorganic biochemistry. 99 (4): 903–11. doi:10.1016/j.jinorgbio.2004.12.001. PMC 10.1016/j.jinorgbio.2004.12.001Freely accessible Check |pmc= value (help). PMID 15811507.  Check date values in: |date= (help)

Jia, Y; Menu, P; Faivre, B; Caron, A; Alayash, AI (11-Jun-2004). "Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran.". Biochimica et biophysica acta. 1672 (3): 164–73. doi:10.1016/j.bbagen.2004.03.009. PMC 10.1016/j.bbagen.2004.03.009Freely accessible Check |pmc= value (help). PMID 15182936.  Check date values in: |date= (help)

Ascenzi, P; Fasano, M; Bertollini, A (Jun-1999). "Stabilization of the T-state of human hemoglobin by proflavine, an antiseptic drug.". Biochemistry and molecular biology international. 47 (6): 991–5. PMID 10410245.  Check date values in: |date= (help)

Yonetani, T; Zhou, Y; Chen, X (7-Aug-1998). "Electron paramagnetic resonance and oxygen binding studies of alpha-Nitrosyl hemoglobin. A novel oxygen carrier having no-assisted allosteric functions.". The Journal of biological chemistry. 273 (32): 20323–33. PMID 9685383.  Check date values in: |date= (help) Nerdseeksblonde (talk) 22:29, 16 November 2009 (UTC)

maybe lifecycle of RBC would help, mention dog/cat problems with onion/garlic for example.[edit]

$ eutilsnew -v -xml -out xxx "onion feline hemolytic"

Hill, AS; Rogers, QR; Christopher, MM (Mar-2001). "Antioxidant prevention of Heinz body formation and oxidative injury in cats.". American journal of veterinary research. 62 (3): 370–4. PMID 11277202.  Check date values in: |date= (help)

Robertson, JE; Rogers, QR (15-Apr-1998). "Heinz body formation in cats fed baby food containing onion powder.". Journal of the American Veterinary Medical Association. 212 (8): 1260–6. PMID 9569166.  Check date values in: |date= (help)

And in dog, Tang, X; Yu, J (Apr-2008). "An experimental study of hemolysis induced by onion (Allium cepa) poisoning in dogs.". Journal of veterinary pharmacology and therapeutics. 31 (2): 143–9. doi:10.1111/j.1365-2885.2007.00930.x. PMC 10.1111/j.1365-2885.2007.00930.xFreely accessible Check |pmc= value (help). PMID 18307506.  Check date values in: |date= (help)

Chang, HS; Yamasaki, M; Ko, M; Maede, Y (1-Jun-2005). "Growth inhibitory effect of alk(en)yl thiosulfates derived from onion and garlic in human immortalized and tumor cell lines.". Cancer letters. 223 (1): 47–55. doi:10.1016/j.canlet.2004.10.008. PMC 10.1016/j.canlet.2004.10.008Freely accessible Check |pmc= value (help). PMID 15890236.  Check date values in: |date= (help)

Chang, HS; Sakai, Y; Yamasaki, M; Maede, Y (Jan-2004). "Acceleration of superoxide generation in polymorphonuclear leukocytes and inhibition of platelet aggregation by alk(en)yl thiosulfates derived from onion and garlic in dogs and humans.". Prostaglandins, leukotrienes, and essential fatty acids. 70 (1): 77–83. PMID 14643182.  Check date values in: |date= (help)

Yamato, O; Kasai, E; Tajima, M; Yamasaki, M; Maede, Y (19-Apr-1999). "Reduced glutathione accelerates the oxidative damage produced by sodium n-propylthiosulfate, one of the causative agents of onion-induced hemolytic anemia in dogs.". Biochimica et biophysica acta. 1427 (2): 175–82. PMID 10216234.  Check date values in: |date= (help)

Yamato, O; Yamasaki, M; Maede, Y (28-Feb-1998). "Induction of onion-induced haemolytic anaemia in dogs with sodium n-propylthiosulphate.". The Veterinary record. 142 (9): 216–9. PMID 9533293.  Check date values in: |date= (help)

Yamoto, O (Jan-1992). "Susceptibility to onion-induced hemolysis in dogs with hereditary high erythrocyte reduced glutathione and potassium concentrations.". American journal of veterinary research. 53 (1): 134–7. PMID 1539905.  Check date values in: |date= (help)

Murase, T (Apr-1990). "Increased erythrophagocytic activity of macrophages in dogs with Babesia gibsoni infection.". Nippon juigaku zasshi. The Japanese journal of veterinary science. 52 (2): 321–7. PMID 2348598.  Check date values in: |date= (help)

Ogawa, E; Akahori, F; Masaoka, T (Aug-1986). "Effect of onion ingestion on anti-oxidizing agents in dog erythrocytes.". Nippon juigaku zasshi. The Japanese journal of veterinary science. 48 (4): 685–91. PMID 3761777.  Check date values in: |date= (help)

Harvey, JW (Jul-1985). "Experimental onion-induced hemolytic anemia in dogs.". Veterinary pathology. 22 (4): 387–92. PMID 4035943.  Check date values in: |date= (help)

van Schouwenburg, S (Sep-1982). "[Hemolytic anemia in a miniature dashshund caused by eating large amounts of onion (Allium cepa)]". Journal of the South African Veterinary Association. 53 (3): 212. PMID 7175912.  Check date values in: |date= (help)

Stallbaumer, M (13-Jun-1981). "Onion poisoning in a dog.". The Veterinary record. 108 (24): 523–4. PMID 7257143.  Check date values in: |date= (help)

Spice, RN (Jul-1976). "Hemolytic anemia associated with ingestion of onions in a dog.". The Canadian veterinary journal. La revue vétérinaire canadienne. 17 (7): 181–3. PMID 949673.  Check date values in: |date= (help)

Some RBS related genes that effect hemolysis susceptibility, Kugler, W (Mar-2000). "Glucose-6-phosphate isomerase deficiency.". Baillière's best practice & research. Clinical haematology. 13 (1): 89–101. PMID 10916680.  Check date values in: |date= (help)

Jacobasch, G (Apr-1996). "Hemolytic anemias due to erythrocyte enzyme deficiencies.". Molecular aspects of medicine. 17 (2): 143–70. PMID 8813716.  Check date values in: |date= (help)

Pohl, A; Moser, K (6-Jul-1984). "[Glucose-6-phosphate dehydrogenase deficiency and other erythrocyte enzyme abnormalities]". Wiener klinische Wochenschrift. 96 (14): 542–8. PMID 6089445.  Check date values in: |date= (help)

Vives-Corrons, JL; Kahn, A; Carrera, A; Triginer, J (7-Oct-1975). "Glucose phosphate isomerase deficiency with hereditary hemolytic anemia in a Spanish family: clinical and familial studies.". Humangenetik. 29 (4): 291–7. PMID 240775.  Check date values in: |date= (help)

Valentine, WN (Oct-1975). "Metabolism of human erythrocytes. Studies in health and disease.". Archives of internal medicine. 135 (10): 1307–13. PMID 1164111.  Check date values in: |date= (help)

Benöhr, HC (10-Jan-1970). "[Hemolytic anemias caused by genetic disorders in human red cells]". Ärztliche Forschung. 24 (1): 19–29. PMID 4398687.  Check date values in: |date= (help)


doi:10.1111/j.1365-2141.2009.08004.x is a review on haemolysis-related vascular changes. Should be able to replace all those references above. JFW | T@lk 11:43, 10 February 2010 (UTC)

Go ahead and ad it somewhere but primary sources are not discouraged here and some aspects generate a tractable number of hits. It is hard to find review articles are free full text so if you could find one like that it would be a great help and establish some context. Nerdseeksblonde (talk) 16:33, 10 February 2010 (UTC)

Heaps of crud[edit]

The following was on the page under "further reading". It shouldn't be in the article. It is hopeless dumping of stuff that someone might once have found interesting. It is preserved here for posterity. JFW | T@lk 20:45, 1 March 2010 (UTC)

Signalling in Normal RBC Collection[edit]

Failure to signal for normal removal is discussed in these papers:

  • Bosman GJ, Lasonder E, Groenen-Döpp YA, Willekens FL, Werre JM, Novotný VM (2009). "Comparative proteomics of erythrocyte aging in vivo and in vitro". Journal of Proteomics. 73: 396. doi:10.1016/j.jprot.2009.07.010. PMID 19660581.  Unknown parameter |month= ignored (help)
  • Kanno H (2008). "[Critical role of phosphatidylserine in hemolysis due to red blood cell enzyme/membrane defects]". Nippon Rinsho (in Japanese). 66 (3): 461–8. PMID 18330023.  Unknown parameter |month= ignored (help)
  • Bratosin D, Mazurier J, Tissier JP; et al. (1997). "Molecular mechanisms of erythrophagocytosis. Characterization of the senescent erythrocytes that are phagocytized by macrophages". Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie. 320 (10): 811–8. PMID 9436535.  Unknown parameter |month= ignored (help)

Related Genetic Conditions[edit]

Some RBC related genes that effect hemolysis susceptibility:

  • Kugler W, Lakomek M (2000). "Glucose-6-phosphate isomerase deficiency". Baillière's Best Practice & Research. Clinical Haematology. 13 (1): 89–101. PMID 10916680.  Unknown parameter |month= ignored (help)
  • Jacobasch G, Rapoport SM (1996). "Hemolytic anemias due to erythrocyte enzyme deficiencies". Molecular Aspects of Medicine. 17 (2): 143–70. doi:10.1016/0098-2997(96)88345-2. PMID 8813716.  Unknown parameter |month= ignored (help)
  • Pohl A, Blechschmidt E, Moser K (1984). "[Glucose-6-phosphate dehydrogenase deficiency and other erythrocyte enzyme abnormalities]". Wiener Klinische Wochenschrift (in German). 96 (14): 542–8. PMID 6089445.  Unknown parameter |month= ignored (help)
  • Vives-Corrons JL, Rozman C, Kahn A, Carrera A, Triginer J (1975). "Glucose phosphate isomerase deficiency with hereditary hemolytic anemia in a Spanish family: clinical and familial studies". Humangenetik. 29 (4): 291–7. doi:10.1007/BF00394191. PMID 240775.  Unknown parameter |month= ignored (help)
  • Valentine WN (1975). "Metabolism of human erythrocytes. Studies in health and disease". Archives of Internal Medicine. 135 (10): 1307–13. doi:10.1001/archinte.135.10.1307. PMID 1164111.  Unknown parameter |month= ignored (help)
  • Benöhr HC (1970). "[Hemolytic anemias caused by genetic disorders in human red cells]". Ärztliche Forschung (in German). 24 (1): 19–29. PMID 4398687.  Unknown parameter |month= ignored (help)

In Cats and Dogs[edit]

Some pets tend to be more susceptible to this than humans. The comparative situations helps illustrate some causes and effects of general interest to hemolysis.

In cats
  • Hill AS, O'Neill S, Rogers QR, Christopher MM (2001). "Antioxidant prevention of Heinz body formation and oxidative injury in cats". American Journal of Veterinary Research. 62 (3): 370–4. doi:10.2460/ajvr.2001.62.370. PMID 11277202.  Unknown parameter |month= ignored (help)
  • Robertson JE, Christopher MM, Rogers QR (1998). "Heinz body formation in cats fed baby food containing onion powder". Journal of the American Veterinary Medical Association. 212 (8): 1260–6. PMID 9569166.  Unknown parameter |month= ignored (help)
And in dog
  • Tang X, Xia Z, Yu J (2008). "An experimental study of hemolysis induced by onion (Allium cepa) poisoning in dogs". Journal of Veterinary Pharmacology and Therapeutics. 31 (2): 143–9. doi:10.1111/j.1365-2885.2007.00930.x. PMID 18307506.  Unknown parameter |month= ignored (help)
  • Chang HS, Yamato O, Yamasaki M, Ko M, Maede Y (2005). "Growth inhibitory effect of alk(en)yl thiosulfates derived from onion and garlic in human immortalized and tumor cell lines". Cancer Letters. 223 (1): 47–55. doi:10.1016/j.canlet.2004.10.008. PMID 15890236.  Unknown parameter |month= ignored (help)
  • Chang HS, Yamato O, Sakai Y, Yamasaki M, Maede Y (2004). "Acceleration of superoxide generation in polymorphonuclear leukocytes and inhibition of platelet aggregation by alk(en)yl thiosulfates derived from onion and garlic in dogs and humans". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 70 (1): 77–83. doi:10.1016/j.plefa.2003.08.006. PMID 14643182.  Unknown parameter |month= ignored (help)
  • Yamato O, Hayashi M, Kasai E, Tajima M, Yamasaki M, Maede Y (1999). "Reduced glutathione accelerates the oxidative damage produced by sodium n-propylthiosulfate, one of the causative agents of onion-induced hemolytic anemia in dogs". Biochimica et Biophysica Acta. 1427 (2): 175–82. doi:10.1016/S0304-4165(99)00023-9. PMID 10216234.  Unknown parameter |month= ignored (help)
  • Yamato O, Hayashi M, Yamasaki M, Maede Y (1998). "Induction of onion-induced haemolytic anemia in dogs with sodium n-propylthiosulphate". The Veterinary Record. 142 (9): 216–9. PMID 9533293.  Unknown parameter |month= ignored (help)
  • Yamoto O, Maede Y (1992). "Susceptibility to onion-induced hemolysis in dogs with hereditary high erythrocyte reduced glutathione and potassium concentrations". American Journal of Veterinary Research. 53 (1): 134–7. PMID 1539905.  Unknown parameter |month= ignored (help)
  • Murase T, Maede Y (1990). "Increased erythrophagocytic activity of macrophages in dogs with Babesia gibsoni infection". Nippon Juigaku Zasshi. 52 (2): 321–7. PMID 2348598.  Unknown parameter |month= ignored (help)
  • Ogawa E, Shinoki T, Akahori F, Masaoka T (1986). "Effect of onion ingestion on anti-oxidizing agents in dog erythrocytes". Nippon Juigaku Zasshi. 48 (4): 685–91. PMID 3761777.  Unknown parameter |month= ignored (help)
  • Harvey JW, Rackear D (1985). "Experimental onion-induced hemolytic anemia in dogs". Veterinary Pathology. 22 (4): 387–92. PMID 4035943.  Unknown parameter |month= ignored (help)
  • van Schouwenburg S (1982). "[Hemolytic anemia in a miniature dashshund caused by eating large amounts of onion (Allium cepa)]". Journal of the South African Veterinary Association (in Afrikaans). 53 (3): 212. PMID 7175912.  Unknown parameter |month= ignored (help)
  • Stallbaumer M (1981). "Onion poisoning in a dog". The Veterinary Record. 108 (24): 523–4. PMID 7257143.  Unknown parameter |month= ignored (help)
  • Spice RN (1976). "Hemolytic anemia associated with ingestion of onions in a dog". The Canadian Veterinary Journal. 17 (7): 181–3. PMC 1697286Freely accessible. PMID 949673.  Unknown parameter |month= ignored (help)

As per comments on your talk page, I'm considering putting this back. An organized further reading list in a stub article needs to be integrated or expanded not removed. If you have something constructive to ad then fine- this is hardly a heap of crud. All of these are potential areas of interest that need to be addressed somewhere in article or at least mentioned. Obviously, people add what is interesting to them and you are free to add to the article not just delete things that would be part of a full article but may currently be out of place or too prominent. Nerdseeksblonde (talk) 01:23, 2 March 2010 (UTC)

What is needed in this article is not a "list that you could read if you've got 500 hours" but a neat bunch of highly reliable sources that supports the current content. At the moment, only the pathophysiology section has references, and they're all primary sources. The list of causes also needs expanding and fixing (it doesn't discuss the MAHAs at all). You are invited to improve the article but I shall be a tad annoyed if you simply put the above list back in. JFW | T@lk 08:25, 2 March 2010 (UTC)
Personally the hardest part about contributing is getting the cites right. If a marginally interested editor familiar with the topic comes along, it is probably easier to delete and move than try to hunt down sources. I'm not trying to make a link farm but med guides iirc single out this area for more concern with primary sources and in this case if you can find reviews are popular culture articles fine but simply deleting a set of catagories here seems to be counterproductive. A serious user already knows what wikipedia states about wikipedia itself being unreliable due to lack of peer review. It would seem then that references are probably preferred to original prose/text short of becoming a link farmor indiscriminanat.Nerdseeksblonde (talk) 12:03, 2 March 2010 (UTC)
There are plenty of highly reliable sources about haemolytic anaemia. I think stuffing the article with numerous references to primary sources about onions causing haemolysis in pets is the bit that's counterproductive. The reliability of Wikipedia content hinges on it being based on reliable sources. Yours, a serious user. JFW | T@lk 14:04, 2 March 2010 (UTC)
I agree with Jfdwolff. Shubinator (talk) 15:05, 2 March 2010 (UTC)
why doesn't that surprise me? Did you ever add anything to the DNDN article? LOL. There are 3 sections above, only 1 deals with non-human animals. Differences in RBC and hemoglobin composition are a big issue here. If you have something to contribute or an organization great but a reader need only read 3 extra heading and determine if any are relevant. This article is certainly not complete and again if you know of important relevant subjects then add and edit for space but right now there is plenty of space. Replacing organized information with nothing is unlikely to help anyone. People who contribute contribute along the lines of their interests, if you aren't interested in the topic change the navigation bar. Nerdseeksblonde (talk) 23:46, 2 March 2010 (UTC)

I'm trying to get the gist of your argument, but I'm not sure if I can. Heaps of references are not a replacement for reliable content, and it is not space I'm concerned about. You wouldn't find a pile of references without an antecedent in a decent encyclopedia article. I am indeed interested in the topic but sadly I care about lots of other topics too. You are free to enhance the current content by expanding it and sourcing it to high-quality references, and I might join you at some point. JFW | T@lk 00:04, 3 March 2010 (UTC)

I give up, surely you are joking. Refereed journal articles and expert opinion is not reliable? Perhaps you have your own blog on the subject you could cite. The issue was never reliability but coherence, relevance, and clutter. I'll let you guys keep hacking it down until there is nothing there. If you know the material and can determine it to be irrelevant or counterproductive then it may not help a reader but 3 high-level headings could only waste a few seconds at worst unless your mouse is slow. References are theonly reliable contenton Wikipedia, by its own criteria wikipedia is not reliable as there is no merit review. We have to go with reliable sources and AFAIK there is a presumption that stuff that comes up on pubmed is either reliable for factual accuracy or represents a prominent view that is seriously considered in a relevant community ( although I doubt suzanne sommers cancer notes come up there LOL). The pet issue illustrates what happens with hemoglobin polymorhpisms which would be a relevant topic. If you can't understand the relevance you may not get the topic. If you have some review articles that may be fine too but usually a few primary source is better for the reader than nothing. Nerdseeksblonde (talk) 22:01, 12 March 2010 (UTC)
We're not worried about space. We are saying that a large link list belongs on the talk page of articles, not on the articles themselves. Readers come to Wikipedia to read a concise summary of the subject, not to spend hours reading journal articles on the topic. Those that want to delve in deeper know where pubmed is. And we've discussed before that secondary sources are preferred over secondary sources. Since our past discussion I've found another link more related to the articles: Wikipedia:Reliable sources (medicine-related articles). Note the Definitions section in particular.
You ask if I added anything to the Dendreon article. No, I didn't, but I offered to help you improve the article, as Jfdwolff has above. We are acting in good faith and willing to help you, so I suggest leaving out the snide comments.
On a lighter note, a pharmaceutical company will be featured on the Main Page in less than two hours. Enjoy! Shubinator (talk) 22:29, 12 March 2010 (UTC)


I propose merging Congenital hemolytic anemia and Acquired hemolytic anemia into this article. This one is not long enough to justify forking. The forks are very much duplicates of what is already written here, and, according to, disappointingly few readers find those forks anyway to make a change to it. If merging, the classification of Template:Diseases of RBCs and megakaryocytes may remain the same, but with unlinked hereditary and acquired. The infoboxes in the forks may be merged too. Mikael Häggström (talk) 06:29, 6 October 2010 (UTC)

On second thought, there are too many "What links here" to justify merging. Mikael Häggström (talk) 06:33, 6 October 2010 (UTC)
There are a number of ways to classify haemolytic anaemia. This is not a bad way of going about it. JFW | T@lk 09:51, 6 October 2010 (UTC)


... complications are quite common. The mechanism is still a bit obscure doi:10.1111/bjh.13183 (review Br J Haem) JFW | T@lk 22:24, 13 October 2014 (UTC)