|WikiProject Chemicals||(Rated Start-class, Mid-importance)|
any artistic chemists out there?
The structure of hydroxyproline doesn't show up (at least in IE5). I'm sure someone would love to do a nice diagram of this, maybe by altering the picture of proline i don't know :-) Tristanb 03:40 3 Jun 2003 (UTC)
The structure of Hydroxyproline shown in this article is wrong. Hyp has its hydroxyl group of the gamma carbon, not the delta carbon. Ref: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=books&doptcmdl=GenBookHL&term=hydroxyproline+AND+mboc4%5Bbook%5D+AND+374347%5Buid%5D&rid=mboc4.figgrp.3556 (and a host of other biochemistry text books)
Ok, I removed the offending image and added a terse description of the difference b/w Pro and Hyp. Sorry, am currently writing up my thesis so I don't have time to create/upload an ammended image!
?? hydroxyproline is an uncommon amino acid ??
This seems like contrary data...
"4-Hydroxyproline, or hydroxyproline (C5H9O3N), is an uncommon amino acid"
"Hydroxyproline is a major component of the protein collagen"
and under Collagen: "Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% of the whole-body protein content."
So if Collagen makes up 25% of the body's protein, and is made from hydroxyproline, how does that make hydroxyproline "uncommon"?
- (2S,4R)-Hydroxyproline is a common amino acid. The formulae in the box should show either (a) (2S,4R)-Hydroxyproline or (b) all four stereoisomers of 4-hydroxyproline. IMO one should select version (b) and explain in the text, that (2S,4R)-Hydroxyproline is the 'normal' proteinogenic amino acid. Best regards, --Jü (talk) 20:43, 13 August 2009 (UTC)
?? The only other mammalian protein which includes hydroxyproline is elastin. ??
The only other mammalian protein which includes hydroxyproline is elastin. For this reason, hydroxyproline content has been used as an indicator to determine collagen and/or gelatin amount.
This is essentially true, BUT, it is also found in many other proteins, e.g. Osteocalcin. It is however not that much, but the sentence is not really true. I have no real good idea how to paraphrase it. And the source  is rather old, so that such a statement is likely do be outdated.--Kosmologie (talk) 13:34, 8 July 2009 (UTC)
Missing stereochemical precision Hydroxyproline
Citation directly from notably HYDROXYPROLINE: "2,3-cis-, 3,4-trans-, and 3,4-dihydroxyproline which occurs in diatom cell walls".... In my opinion it remains completely unclear, what isomer/analog/derivative is found in cell walls. Why? There are several different stereoisomers of (a) 2,3-cis-dihydroxyproline, (b) 3,4-trans-dihydroxyproline and (c) 3,4-dihydroxyproline. More precise information is required. Best regards, --Jü (talk) 20:34, 13 August 2009 (UTC)