Talk:Hydroxyproline

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Untitled[edit]

any artistic chemists out there?

The structure of hydroxyproline doesn't show up (at least in IE5). I'm sure someone would love to do a nice diagram of this, maybe by altering the picture of proline i don't know :-) Tristanb 03:40 3 Jun 2003 (UTC)

Here's proline:
File:Pro-stick.png

The structure of Hydroxyproline shown in this article is wrong. Hyp has its hydroxyl group of the gamma carbon, not the delta carbon. Ref: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=books&doptcmdl=GenBookHL&term=hydroxyproline+AND+mboc4%5Bbook%5D+AND+374347%5Buid%5D&rid=mboc4.figgrp.3556 (and a host of other biochemistry text books)

Ok, I removed the offending image and added a terse description of the difference b/w Pro and Hyp. Sorry, am currently writing up my thesis so I don't have time to create/upload an ammended image!

?? hydroxyproline is an uncommon amino acid ??[edit]

This seems like contrary data...

"4-Hydroxyproline, or hydroxyproline (C5H9O3N), is an uncommon amino acid"

"Hydroxyproline is a major component of the protein collagen"

and under Collagen: "Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals,[1] making up about 25% of the whole-body protein content."

So if Collagen makes up 25% of the body's protein, and is made from hydroxyproline, how does that make hydroxyproline "uncommon"?

Guess I'm missing something here. —Preceding unsigned comment added by 68.200.111.83 (talk) 06:24, 24 August 2008 (UTC)

(2S,4R)-Hydroxyproline is a common amino acid. The formulae in the box should show either (a) (2S,4R)-Hydroxyproline or (b) all four stereoisomers of 4-hydroxyproline. IMO one should select version (b) and explain in the text, that (2S,4R)-Hydroxyproline is the 'normal' proteinogenic amino acid. Best regards, -- (talk) 20:43, 13 August 2009 (UTC)

?? The only other mammalian protein which includes hydroxyproline is elastin. ??[edit]

The only other mammalian protein which includes hydroxyproline is elastin.[7] For this reason, hydroxyproline content has been used as an indicator to determine collagen and/or gelatin amount.

This is essentially true, BUT, it is also found in many other proteins, e.g. Osteocalcin. It is however not that much, but the sentence is not really true. I have no real good idea how to paraphrase it. And the source [7] is rather old, so that such a statement is likely do be outdated.--Kosmologie (talk) 13:34, 8 July 2009 (UTC)

Missing stereochemical precision Hydroxyproline[edit]

Citation directly from notably HYDROXYPROLINE: "2,3-cis-, 3,4-trans-, and 3,4-dihydroxyproline which occurs in diatom cell walls".... In my opinion it remains completely unclear, what isomer/analog/derivative is found in cell walls. Why? There are several different stereoisomers of (a) 2,3-cis-dihydroxyproline, (b) 3,4-trans-dihydroxyproline and (c) 3,4-dihydroxyproline. More precise information is required. Best regards, -- (talk) 20:34, 13 August 2009 (UTC)

hydroxyproline occurs in the body..and the body consists of fish, water, and eggs. —Preceding unsigned comment added by 75.117.146.208 (talk) 20:28, 2 February 2010 (UTC)