Talk:Multiple system atrophy
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|WikiProject Medicine||(Rated B-class, Mid-importance)|
- 1 ICD-9 and ICD-10 Codes
- 2 Olivopontocerebellar atrophy
- 3 Etiology?
- 4 Onset/Diagnosis: Two NIH sites
- 5 Merging in Shy-Drager syndrome
- 6 Cause of death
- 7 Link to a Multiple System Atrophy (MSA) information site
- 8 Meaning of difference in prevalence between men and women
- 9 A parallel project on Wikiversity?
- 10 "There is no remission from the disease." (a line in Prognosis)
- 11 external links
ICD-9 and ICD-10 Codes
I din't change the "infobox" with ICD-9 and ICD-10 codes, but don't understand the significance of the "Name:" in that box. This is neither the "name" of the ICD-9 code nor the name of the disease this article about. So what is it? --Sjsilverman 02:09, 19 December 2005 (UTC)
- That's what the condition is called in ICD-10 . But I've made the change to "Multiple system atrophy" so it matches the article name. --Arcadian 02:40, 19 December 2005 (UTC)
This article states that the term "Olivopontocerebellar atrophy" is obsolete. Wikipedia has had an article for Olivopontocerebellar atrophy since 15 December 2004, and I'm trying to figure out if we should treat it like Shy-Drager syndrome (maintained only as a historical entry). Any thoughts? --Arcadian 16:43, 1 February 2006 (UTC)
- The term "Multiple system atrophy" encompasses (replaces) the terms "Olivopontocerebellar atrophy (OPCA)", "Shy-Drager syndrome", and "Striatonigral degeneration" based on similar pathological findings and frequent overlapping clinical symptoms. Reference: ACNR Jan/Feb 2004; vol. 3 (no. 6): pp. 5-10. 18.104.22.168 (talk · contribs)
My understanding is that the current working theory is that there is a genetic predisposition (non-hereditary) that is activated by some sort of enviornmental, viral or bacterial "event". Since so many of the neurons in the affected areas have to be damaged before symptoms appear it is possible that the neurons begin dying very early in life. —Preceding unsigned comment added by 22.214.171.124 (talk) 15:47, 7 August 2009 (UTC)
Onset/Diagnosis: Two NIH sites
NIDS site states: "MSA affects both men and women, primarily in their 50s." http://www.ninds.nih.gov/disorders/msa/msa.htm Medline Plus Dictionary states "MSA develops gradually and is most often diagnosed in men older than 60." I realize that these two statements aren't logically inconsistent, but, taken by themselves, would lead the reader to different conclusions. Anyone know if both are correct? --Sjsilverman (talk) 03:07, 26 November 2008 (UTC)
- All I can think of is that perhaps MSA is slightly easier to dissociate in men from Parkinson's disease because of the early presentation of erectile dysfunction, whereas you have to go on orthostatic hypotension etc. in women? Either way, I don't think there are enough studies to say conclusively one way or the other. Let me have a little dig through the recently published NNIPS study and add that in. --PaulWicks (talk) 13:54, 26 November 2008 (UTC)
Merging in Shy-Drager syndrome
Cause of death
Link to a Multiple System Atrophy (MSA) information site
I created an maintain a web site on MSA. It contains information on MSA with links to other sites, but its primary raison d'etre was to provide a diary style record of someone going through the phases of MSA.
I have been asked by the major on line support group not to let this web site disappear.
As I have removed the web counter, I no longer know how many hits I get but I do know from emails received that the site is visited regularly.
When I type "multiple system atrophy" into Google, the Wikipedia web page is the first entry displayed and my web site at www.surfcoastwombat.com is the second entry displayed.
I believe that there is a case for a link on your page to my web site and I think the email below which I have copied and pasted into this message shows why.
I will shortly be adding a link on my pages to the Wikipedia entry.
Regards John Cummings firstname.lastname@example.org
- I have removed the pasted email which, while touching, absolutely does not belong here. The web site looks useful enough that I myself would not revert the link, although I can't guarantee that nobody else will. On behalf of readers there are a couple of changes you could make that would make me more comfortable linking there: (1) Get rid of the flashing. Flashing stuff on web pages is horrible, as it constantly distracts attention from anything else. (2) Use a more readable font. The one used is attractive, but makes it too difficult to get the words. Regards, Looie496 (talk) 21:57, 12 October 2010 (UTC)
Meaning of difference in prevalence between men and women
A 2001 article in Molecular Pathology is cited in the last sentence of the Prevalence section to support the proposition that "Some believe that the higher ratio may be due to greater environmental exposure to putative toxins in men, or difference in endogenous protective factors (hormonal) in women." In fact, the only reference to this theory in the cited article is as follows:
- A male predominance of 1.4 : 1 was reported by Quinn in a review of 231 pathologically confirmed MSA cases.14 If confirmed, this observation may have aetiological relevance. For example, there may be greater environmental exposure to putative toxins in men, or endogenous protective factors (hormonal perhaps) in women.
(emphasis added) Burn DJ, Jaros E. Multiple system atrophy: cellular and molecular pathology. Mol Pathol 2001;54:419 – 426.
This passing reference in an article on molecular pathology is, on its face, speculation that is merely intended to suggest how disparities in prevalence could have possible "aetiological relevance." Nothing in the article suggests that the authors or anyone else believe this to be the case. I've therefore deleted. --Federalist51 (talk) 00:20, 12 January 2012 (UTC)
A parallel project on Wikiversity?
I am currently involved with a few others on a learning project on the science behind Parkinson's disease on Wikiversity - see V:Portal:The_Science_Behind_Parkinson's. If any of the contributors to the wikipedia MSA page would like to join us developing the Wikiversity project you would be more than welcome.
But this note is really to ask if anyone would be interested in starting a wikiversity learning project of a similar nature on the science behind MSA. I envision it would, too, attempt to follow the research on MSA as it progresses and discuss the significance of new results and the issues raised.
"There is no remission from the disease." (a line in Prognosis)
I am not trained in medicine or any sub-field thereof, but this line just sounds overly short, blunt, and harsh to me (even considering that MSA is in fact a terminal illness). It's like typing "YOU ARE DEAD" in big letters. Could it at least be reworded as "The disease is terminal" or some variant? Admiral.Mercurial (talk) 11:38, 30 September 2014 (UTC)
Hi, Ozzie10aaaa, not sure why you removed the external links from this article, as this is one place where they are deemed to be appropriate. Were they in some way flawed? Let me know, as I just replaced them in the relevant "External links" section.--Quisqualis (talk) 01:53, 14 February 2018 (UTC)
- Quisqualis,so...if we go to Wikipedia:Manual of Style/Medicine-related articles#External links it indicates Don't use external links...to web-based or email-based support groups for patients, professionals, or other affected people (even if run by a charitable organization)...(will post on talk/article as well)--Ozzie10aaaa (talk) 02:44, 14 February 2018 (UTC)