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History: London Hospital
It should probably be noted that London Hospital were the first to use radiotherapy, and expanded research in the field extensively. I came here to find more information on the historic application at London Hospital and was disappointed to find it's not even mentioned when it was so integral in development and use of radiotherapy. Poor form. 126.96.36.199 (talk) 22:01, 23 March 2011 (UTC)
Mechanism of action
The following is nonsense: "The cyclotron's, dielectric wall accelerator (DWA), or Still River Systems's super conducting high field magnet (two new compact protron replacements) provide the energy source for charged particle therapy. These particles can be charged to different amounts to provide the desired tissue penetration."
The electric charge of the proton in a constant, protons can not be charged to different amounts. Magnets are used for steering or focusing the beam, not as "energy source". There are just no "proton replacements", sorry. — Preceding unsigned comment added by 188.8.131.52 (talk) 18:41, 6 August 2011 (UTC)
There is no evidence in the literature that I'm aware of that suggests that cancerous cells have turned off their DNA repair mechanisms. This should be cited at the very least. 184.108.40.206 (talk) 02:51, 30 November 2011 (UTC)
The article says that cancer cells often have DEFECTIVE DNA repair, which is quite different from DNA repair turned off. Problems with DNA repair (e.g: mutated p53, Rb) are very well documented in cancer.Jellytussle (talk) 15:20, 2 December 2011 (UTC)
The article states in the introduction:
It is believed that cancerous cells may be more susceptible to death by this process as many have turned off their DNA repair ability during the process of becoming cancerous.
A citation would help clarify this statement - I'm aware that impaired DNA repair mechanisms occur but this causes extreme radiosensitivity and the more likely explanation is that cell death occurs due to incomplete and/or improper DNA repair mounting up over a few mitotic divisions as the cell's DNA repair mechanism is incapable of dealing with the higher frequency of DSBs induced by ionising radiation. 220.127.116.11 (talk) 23:50, 4 December 2011 (UTC)
Part of the DNA repair process is telomerase activation and the extension of telomeres, which allow the cancer stem cell to continue replication without encountering the Hayflick limit on growth. Certainly telomerase is turned on in cancer stem cells and the telomerase gene is a master cancer gene that causes about 214 other genes to switch to cancer mode (per Elizabeth Blackburn webcast, Nobel in Medicine) About 60 of the switched genes are associated with promoting cellular replication so far. Robert A. Weinberg, an important cancer researcher can create cancer in "many human cell types" , switching only 3 master genes, without using a carcinogen, he turns on Telomerase in every case, turns off a tumor suppressor gene, and turns on an oncogene. But the point is, cancer greatly relies on the DNA repair process and overexpressed telomerase to grow fast , and divide without encountering the Hayflick Limit. Sourced from Geron presentations, Blackburn's webcasts and papers. Also, an associate of Blackburn, Mohamed Sabet, was able to return melanoma cells to originial pigmentation by inhibiting telomerase. Geron is testing telomerase inhibitor, Imetelstat, now in multiple FDA human trials for multiple caner types. Cancer cells without an intact RNA binding site on it's telomerase, loses it's replicative immortality, and could cause the reversal of the massive gene switching. Imetelstat binds tightly to the RNA template of telomerase that is the active site of telomere extension. — Preceding unsigned comment added by Prime3end (talk • contribs) 17:04, 9 December 2011 (UTC)
Radiation makes Cancer Stem Cells grow faster
I've read a piece of research that claims that ionizing radiation makes cancer stem cells grow faster, unless they receive enough to be killed by it. Since the cancer stem cells do most of the growing, this seems important to address on the main page. Some cancer stem cells are quiescent (G e r o n Corp) and emerge after chemo with chemo resistance. The culprit in cancer is the cancer stem cell, and radiotherapy, heat/light therapies need to have targeting and imaging technology that can illuminate cancer stem cells and even identify single cells for targeting, when radiation, light/heat , or even chemo are the treatment. I hope someone will do the legwork for links, the work has been done, it's out there. — Preceding unsigned comment added by Prime3end (talk • contribs) 16:52, 9 December 2011 (UTC)
File:Axesse Radiotherapy.png Nominated for Deletion
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Agree Delete. Refers to specific commercial interest. Not about radiotherapy per se. Not even one of the major linac or software manufacturers.Adds nothing to the page. Jellytussle (talk) 16:53, 17 June 2012 (UTC)
I searched PubMed, Google Scholar, and the Cochrane Library for papers on indications for radiation therapy. I was unable to find a single paper giving an overview of the topic, as most papers only talk about indications for a single condition. If there was an overview anywhere then I might guess that it would be in a textbook. Anyway, I did not find one. Blue Rasberry (talk) 15:16, 1 November 2013 (UTC)