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- 1 Name? Sirolimus vs Rapamycin
- 2 Autism section
- 3 Structure?
- 4 Sirolimus/ Late Thrombosis
- 5 More precise longevity statement
- 6 Cost - use of grapefruit
- 7 Patents
- 8 Removed report of in-vitro work
- 9 Wyeth is now Pfizer
- 10 Anti proliferative
- 11 Serolimus (rapamycin) in Sleep regulation
- 12 Alzheimer's Disease
- 13 Orphaned references in Sirolimus
- 14 IL-2 production or signal inhibited??
Name? Sirolimus vs Rapamycin
Should the drug really be listed as its trade name, rather than the common chemical one? btavshanjian
I agree, all other drug articles i've seen on WP are under their chemical name, not their trade name, especially since the trade name can differ across countries. --18.104.22.168 (talk) 00:39, 15 July 2009 (UTC)
Looking at popularity, "Rapamycin" produces 11372 records on PubMed, "Sirolimus" gives 8178. I think it also makes sense to have the title of the article be "rapamycin" since the intro paragraph gives the origin of the term "rapa". I don't know how the INN/USAN factor weighes into this arguement. --Tea with toast (talk) 01:36, 29 October 2009 (UTC)
- Per WP:MEDMOS, INNs should always be used as article titles. I am a major supporter of this guideline, which is in keeping with the original purpose of INNs—providing a completely unambiguous, internationally recognizable names with no industry or trade connotations. Fvasconcellos (t·c) 03:21, 29 October 2009 (UTC)
If there is complete consensus on this, is the trade name used only because some company PR people are dominating the site? — Preceding unsigned comment added by 22.214.171.124 (talk) 01:28, 20 August 2012 (UTC) In the section on "Autism in Mice" the cited research paper does not mention "Sirolimus" at all, only "Rapamycin" so in the interest of accuracy I changed the names to agree with the citation. — Preceding unsigned comment added by 126.96.36.199 (talk) 01:37, 20 August 2012 (UTC)
- Maybe Fvasconcellos didn't make himself entirely clear: "Sirolimus" is not the trade name but the International Nonproprietary Name (INN). Rapamycin is an old name that is still often seen, but we should stick with our guidelines (WP:MOSMED#Drugs, medications and devices) and use the INN, "sirolimus". Also, I think it is confusing to use different names for the same substance, depending on how the respective sources call it -- therefore I'll undo your last edit, although I'm aware you had good intentions. Please tell me (preferably here) if you disagree. Cheers, ἀνυπόδητος (talk) 10:52, 20 August 2012 (UTC)
I don't think so personally. Standard IQ tests that are used to diagnose and define retardation unfortunately rely heavily on verbal skills. If there is anyone out there that knows of a testing method that defines congnitive ability independantly of verbal skill, I would like to hear of it. It is unfair to those affected by ASD to not separate the two. How to do that may be another question!Melanie.brown35 (talk) 22:19, 29 January 2009 (UTC)
Is the stereochemistry of the structure correct? I'm finding differences in online structures as to what the stereochemistry to the methyl group near the lactone should be. (Hashed bond in upper left) (Also posted on image talk page)-- 16:07, 31 January 2007 (UTC)
- I created the image using Image:Sirolimus1.gif as a model, then checked it for accuracy against CID 6436030 from PubChem. If the stereochemistry is inaccurate, I apologize; I'll try to find alternate sources and re-check. Fvasconcellos 22:51, 31 January 2007 (UTC)
Sirolimus/ Late Thrombosis
Inclusion of the statement of the rapamycin DES stent (known as Cypher and sometimes denoted as SES) may be misleading since the exact reason is debatable. One postulate includes what Dr. Renu Virmani at Armed Forces Reseach Laboratories calls a polymer hypersensitivity. If this is correct, then the statement should be included on a Wikipedia page on the Cypher stent and not on the rapamycin/sirolimus page. CClaude 188.8.131.52 (talk) 20:00, 2 December 2008 (UTC)
More precise longevity statement
"A 2009 study indicated that rapamycin can prolong the life of mice. If this increase in lifespan were translated to human years, it might allow humans to live more than a hundred years". That could use a rewrite. Something like, "If these results were replicable in humans, average lifespan could be extended to over 100 years." 184.108.40.206 (talk) 22:46, 9 July 2009 (UTC)
Cost - use of grapefruit
A comment regarding the use of grapefruit to lower doses and costs of the drug have been frequently added or removed over the past few months. I have deleted the comment.
Grapefruit (and many other foods) is an inhibitor of CYP450 and will affect the metabolism of many drugs. The CYP450 wiki entry gives more detail.
The referenced US patent 5,665,7220 does not exist, in fact it has one too many digits to be a valid patent number. The earliest US patent referencing rapamycin is 3,929,992 filed in 1974, although 5,675,732 claims a more efficient means of production and would only recently have expired. 220.127.116.11 (talk) 13:46, 6 August 2010 (UTC)
- Also 5,212,155 expires in Nov 2010 and 5,100,899 expires Jan 7, 2014 (both re inhibiting transplant rejection)  Rod57 (talk) 11:38, 8 October 2010 (UTC)
Removed report of in-vitro work
Removed from cancer section as not notable (re sirolimus) since only in-vitro :
Panobinostat has been found to synergistically act with sirolimus to kill pancreatic cancer cells in the laboratory in a Mayo Clinic study. In the study, investigators found that this combination destroyed up to 65 percent of cultured pancreatic tumor cells. The finding is significant because the three cell lines studies were all resistant to the effects of chemotherapy-as are many pancreatic tumors.[Removed report of in-vitro work 1]
Wyeth is now Pfizer
Serolimus (rapamycin) in Sleep regulation
At least one studie is using rapamycin as the drug name when reporting its use in sleep and circadian rhythm research in a PLoS Biology paper.
Athanasios Metaxakis, Luke S. Tain, Sebastian Grönke, Oliver Hendrich, Yvonne Hinze, Ulrike Birras, Linda Partridge. Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila. PLoS Biology, 2014; 12 (4): e1001824 DOI: 10.1371/journal.pbio.1001824  
"Because sirolimus is already approved for other indications, it should be easy to start a clinical trial to see whether it works in humans." One or more doctors treating Alzheimer's patients may have already prescribed sirolimus, observed that it had no effect at all, and never published the negative results.Schmausschmaus (talk)
I check pages listed in Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of Sirolimus's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.
Reference named "pmid22168436":
- From David M. Sabatini: Magnuson B, Ekim B, Fingar DC (January 2012). "Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks". Biochem. J. 441 (1): 1–21. PMID 22168436. doi:10.1042/BJ20110892.
- From Mechanistic target of rapamycin: Magnuson B, Ekim B, Fingar DC (January 2012). "Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks". Biochem. J. 441 (1): 1–21. PMID 22168436. doi:10.1042/BJ20110892.
I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT⚡ 12:17, 4 March 2016 (UTC)
IL-2 production or signal inhibited??
Currently the first paragraph ends with: "It inhibits activation of T cells and B cells by reducing the production of interleukin-2 (IL-2)." I am confused, as later it is said to inhibit the signal transduction of the IL-2 receptor. I'm changing this sentence to reflect the information I found on https://compendium.ch/mpro/mnr/21159/html/de#7550 (unfortunately not an english source). If someone could verify this and add an english citation, that would of course be great! --18.104.22.168 (talk) 16:11, 12 January 2017 (UTC)
- Rapamycin acts exclusively by inhibiting mTOR. In the case of lymphocytes, this causes their arrest at the G1/S checkpoint and prevents IL-2 synthesis. Such immunosuppressive effects have been described in detail for the past 20 years, see e.g. http://www.jbc.org/content/270/16/9454.abstract and http://www.sciencedirect.com/science/article/pii/0024320595022333 Cheers. Neodop (talk) 18:54, 12 January 2017 (UTC)
- Max-Planck-Gesellschaft. (2014, April 1). Well-rested flies: Therapeutic agent reduces age-related sleep problems in fruit flies. ScienceDaily. Retrieved July 10, 2015 from www.sciencedaily.com/releases/2014/04/140401173138.htm
- PLOS. (2014, April 1). Age-related decline in sleep quality might be reversible. ScienceDaily. Retrieved July 10, 2015 from www.sciencedaily.com/releases/2014/04/140401173130.htm