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Thiazides in Chronic Kidney Disease[edit]

Thiazide are recommended in patients with hypertension & Chronic kidney disease when GFR >= 30 ml/min (Stages 1-3) according to the National Kidney Foundation KDOQI Guidelines. — Preceding unsigned comment added by Regarr (talkcontribs) 23:13, 28 January 2016 (UTC)

Thiazides raise homocysteine levels, cite specifics for folate supplementation[edit]

The article says that thiazides raise homocysteine levels (for which there is reasonable evidence), and goes on to say "It is recommended that patients receiving long-term thiazide treatments also receive folic acid supplements to combat the risk" without any citation. I can't find any source for this in treatment guidelines, drug labelling, or a couple of pharmacology reference books. Recommendations would probably differ by country according to how much folate fortification was in ordinary foods. 19:14, 4 July 2007 (UTC)


i read it quickly but i don't think the hyponatremia effect from taking thiazides was explained. Please add this information. -- lose ability to dilute urine. —Preceding unsigned comment added by Tkjazzer (talkcontribs) 06:58, 11 October 2007 (UTC)

Thiazide-induced diabetes[edit]

This article cites a new issue of Hypertension (journal), specifically Shafi T, Appel LJ, Miller ER III, Klag MJ, Parekh RS. "Changes in serum potassium mediate thiazide-induced diabetes". Hypertension. 52: 1022–1029. doi:10.1161/HYPERTENSIONAHA.108.119438. thiazide-induced diabetes occurs early after initiating treatment and appears to be mediated by changes in serum potassium  LeadSongDog (talk) 20:50, 25 November 2008 (UTC)

I would add this to the main article in my opinion. (talk) 13:32, 29 January 2011 (UTC)


can you have sulfa allergy to this? shouldn't each drug have an allergy sub-section. thanks. —Preceding unsigned comment added by (talk) 23:42, 13 December 2008 (UTC)


as far as I know there is the exact opposite SE- hyperkalemia. Am I wrong? —Preceding unsigned comment added by Yonigros (talkcontribs) 06:18, 3 April 2009 (UTC)

Not unless you wreck the renal function somewhere along the way. JFW | T@lk 22:30, 9 November 2009 (UTC)

Moser[edit] - review by Marvin Moser, historical. JFW | T@lk 22:30, 9 November 2009 (UTC)

Efficacy in reducing cardiovascular diseases?[edit]

No mention of heart attacks or strokes. Imagine Reason (talk) 12:33, 7 December 2009 (UTC)

? "The thiazides and thiazide-like diuretics reduce the risk of death, stroke, heart attack and heart failure due to hypertension, and, as of 2009, the best available evidence favors them as the first choice of treatment for high blood pressure when drugs are necessary." Fvasconcellos (t·c) 12:38, 7 December 2009 (UTC)

Article should mention how long thiazides typically take to become effective.[edit]

What is the expected response curve, in terms of results in the first days, weeks, etc.

Article should mention JNC7 "first line" recommendation.[edit]

The JNC7 "first line" recommendation should at least be mentioned. — Preceding unsigned comment added by (talk) 21:48, 12 February 2012 (UTC)

Definition missing[edit]

I don't see a definition of what "thiazide" means. The lede describes qualities of it, but not what it actually is (is it a certain substructure, or biochemical target, or natural origin, or...?). DMacks (talk) 04:44, 19 December 2015 (UTC)