Tetrahydrocannabinolic acid synthase
| Tetrahydrocannabinolic acid synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.21.3.7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tetrahydrocannabinolic acid synthase (EC 1.21.3.7, THCA synthase, Delta1-tetrahydrocannabinolic acid synthase) is an enzyme with systematic name cannabigerolate:oxygen oxidoreductase (cyclizing, Delta9-tetrahydrocannabinolate-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction
- cannabigerolate + O2 Delta9-tetrahydrocannabinolate + H2O2
Tetrahydrocannabinolic acid synthase is a flavoprotein (FAD).
References
- ^ Taura, F.; Morimoto, S.; Shoyama, Y.; Mechoulam, R. (1995). "First direct evidence for the mechanism of Δ1-tetrahydrocannabinolic acid biosynthesis". J. Am. Chem. Soc. 117: 9766–9767. doi:10.1021/ja00143a024.
- ^ Sirikantaramas, S.; Morimoto, S.; Shoyama, Y.; Ishikawa, Y.; Wada, Y.; Shoyama, Y.; Taura, F. (2004). "The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Δ1-tetrahydrocannabinolic acid synthase from Cannabis sativa L". J. Biol. Chem. 279 (38): 39767–39774. doi:10.1074/jbc.M403693200. PMID 15190053.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Shoyama, Y.; Takeuchi, A.; Taura, F.; Tamada, T.; Adachi, M.; Kuroki, R.; Shoyama, Y.; Morimoto, S. (2005). "Crystallization of Δ1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 8): 799–801. doi:10.1107/S1744309105023365. PMID 16511162.
- ^ Shoyama, Y.; Tamada, T.; Kurihara, K.; Takeuchi, A.; Taura, F.; Arai, S.; Blaber, M.; Shoyama, Y.; Morimoto, S.; Kuroki, R. (2012). "Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa". J. Mol. Biol. 423 (1): -. doi:10.1016/j.jmb.2012.06.030. PMID 22766313.
External links
- Tetrahydrocannabinolic+acid+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)