|Thuja standishii foliage and cones |
upper side left, under side right
Thuja standishii (Japanese thuja; nezuko, kurobe) is a species of thuja, an evergreen coniferous tree in the cypress family Cupressaceae. It is native to southern Japan, where it occurs on the islands of Honshū and Shikoku. It is a medium-sized tree, reaching 20–35 m tall and with a trunk up to 1 m diameter.
The foliage forms in flat sprays with scale-like leaves 2–4 mm long, matte green above, and with narrow white stomatal bands below. The cones are oval, yellow-green ripening red-brown, 6–12 mm long and 4–5 mm broad (opening to 8 mm broad), with 6–10 overlapping scales.
There is some evidence that extracts of T. standishii have biological activity. It contains a compound called standishinal which has shown relatively potent effects on the enzyme aromatase. It acts as an inhbitor, thus decreasing the synthesis of Estradiol in the human body. This compound has been used in research and derivatives of it have shown even stronger inhibition of Aromatase.
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- Ohtsu, Hironori; Iwamoto, Manabu; Ohishi, Hirofumi; Matsunaga, Shunyo; Tanaka, Reiko (1999). "Standishinal, a novel carbon skeletal diterpene from the bark of Thuja standishii (Gord.) Carr". Tetrahedron Letters. 40 (35): 6419–6422. doi:10.1016/S0040-4039(99)01191-0.
- Katoh, Takahiro; Akagi, Taichi; Noguchi, Chie; Kajimoto, Tetsuya; Node, Manabu; Tanaka, Reiko; Nishizawa (Née Iwamoto), Manabu; Ohtsu, Hironori; Suzuki, Noriyuki; Saito, Koichi (2007). "Synthesis of dl-standishinal and its related compounds for the studies on structure–activity relationship of inhibitory activity against aromatase". Bioorganic & Medicinal Chemistry. 15 (7): 2736–2748. doi:10.1016/j.bmc.2007.01.031. PMID 17287126.