From 1915 to 1916, Hughitt was the head football coach at the University of Maine. He compiled a 6–7–3 overall record, including the Maine Intercollegiate Athletic Association championship in 1915. An article in The Michigan Technic commented on Hughitt's success at Maine:
"Due to the excellent coaching of 'Tommy' Hughitt, former varsity quarterback, the University of Maine football tam won the state championship this season. Hughitt showed the effectiveness of the Yost system of coaching by developing a bunch of green material, a tam which staged a real 'comeback' after a bad start last year. Maine is highly pleased with the work of Hughitt and has engaged him for this season."
When the Prospects joined the ranks of the APFA (later known as the National Football League) in 1920, Hughitt was retained as the centerpiece of the now-renamed Buffalo All-Americans. During his APFA/NFL career, Hughitt was a triple threat man and player-coach at the same time, playing quarterback, wide receiver, running back, punter, placekicker, and playing on defense all the while coaching the team. He finished his career with an impressive 29–15–7 record, two state championships (1918 and 1919), two top-three finishes in the NFL (1920 and 1921), and statistically finishing at or near the top of the league in several scoring and receiving categories in 1920 and 1921 (the one-two punch of Hughitt and Ockie Anderson was one of the most potent in the nascent league); he never had a losing season in his entire time as coach. He retired from football in 1924, shortly after acquiring a stake in his team. After Hughitt's departure, he handed over the reins of the franchise to Walter Koppisch, and Hughitt spent time as a league official.
In 1937, he became a councilman for the City of Buffalo serving for a term of four years. He died in Bartow, Florida and was buried in Buffalo. He was elected to Michigan’s Upper Peninsula Sports Hall of Fame in 1992. However despite his record, Hughitt has never been considered for the Pro Football Hall of Fame.