Transmembrane protein 44

TMEM44
Identifiers
Aliases	TMEM44, transmembrane protein 44
External IDs	MGI: 1924489 HomoloGene: 26702 GeneCards: TMEM44
Gene location (Human)
Chr.	Chromosome 3 (human)
End	194,633,689 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	30,550,842 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; rectum; ; stromal cell of endometrium; ; sural nerve; ; spleen; ; minor salivary glands; ; caudate nucleus; ; putamen; ; canal of the cervix;
	Top expressed in
	ganglionic eminence; ; neural tube; ; superior frontal gyrus; ; prefrontal cortex; ; hippocampus proper; ; mesencephalon; ; right lung; ; atrium; ; olfactory bulb; ; nucleus accumbens;
	More reference expression data
	n/a
Gene ontology
Molecular function	L-lysine transmembrane transporter activity; L-arginine transmembrane transporter activity; basic amino acid transmembrane transporter activity;
Cellular component	membrane; lysosomal membrane; integral component of membrane;
Biological process	L-lysine transmembrane transport; L-arginine transmembrane transport; basic amino acid transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	93109
	224090
	ENSG00000145014
	ENSMUSG00000022537
	Q2T9K0
	n/a
	NM_001011655; NM_001166305; NM_001166306; NM_138399
	NM_172614; NM_001357413; NM_001357414; NM_001357415; NM_001361297
	NP_001011655; NP_001159777; NP_001159778; NP_612408
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 44 is a protein that in humans is encoded by the TMEM44 gene. ^[5]

Gene[edit]

mRNA sequence of the TMEM44 gene is 1483 base pairs long, with 13 exons.^[6]

Locus[edit]

TMEM44 gene is located at the end of the long arm of chromosome 3 in humans (Homo sapiens).^[7]

TMEM44 gene on human chromosome 3

Protein[edit]

TMEM44 is 428 amino acids in length. The molecular weight of the protein is 47.1kDa, and its formula is C₂₀₈₆H₃₃₁₅N₅₈₅O₆₁₁S₂₂, with a total of 6619 atoms.^[8] TMEM44 is predicted to be integrated in the plasma membrane of the endoplasmic reticulum.

Expression[edit]

There is an overall low level expression of TMEM44 protein throughout the developmental stages of an organism.^[9]

Transcripts[edit]

There are 12 isoforms of TMEM44 including isoform a, isoform b, isoform c, isoform d, isoform X1, isoform X2, isoform X3, isoform X4, isoform X5, isoform X6, isoform X7, isoform X8.^[7]

Transmembrane Region Allocation[edit]

There are seven predicted transmembrane domains in TMEM44 protein.

Interacting Proteins[edit]

GSK3B (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with TMEM44.^[10]^[11]^[12]

Post-Translational Modification[edit]

TMEM44 is predicted to undergo threonine, tyrosine and serine phosphorylations.^[13]

Orthologs[edit]

TMEM44 orthologs includes groups such as amphibians, birds, fish, mammals.^[14]

Paralogs[edit]

Predicted paralogous proteins of TMEM44 are C9IZ85, F8WCY1, F8WE47, H7C3X7, J3KQW3, Q6PL43, and Q96I73.^[15]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145014 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022537 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Transmembrane protein 44". Retrieved 2018-05-01.
^ "Homo sapiens transmembrane protein 44, mRNA (cDNA clone IMAGE:4747146) - Nucleotide - NCBI". www.ncbi.nlm.nih.gov. 16 March 2005. Retrieved 2018-02-18.
^ ^a ^b "TMEM44 transmembrane protein 44 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-15.
^ "ExPASy - ProtParam tool". web.expasy.org. Retrieved 2018-04-22.
^ Group, Schuler. "EST Profile - Hs.478729". www.ncbi.nlm.nih.gov. Retrieved 2018-04-23.
^ IntAct. "IntAct Portal". www.ebi.ac.uk. Retrieved 2018-04-22.
^ Lab, Mike Tyers. "BioGRID | Database of Protein, Chemical, and Genetic Interactions". thebiogrid.org. Retrieved 2018-04-22.
^ "The Molecular INTeraction Database – An ELIXIR Core Resource". mint.bio.uniroma2.it. Retrieved 2018-04-22.
^ "NetPhos 3.1 Server". www.cbs.dtu.dk. Retrieved 2018-04-22.
^ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2018-02-18.
^ Database, GeneCards Human Gene. "TMEM44 Gene - GeneCards | TMM44 Protein | TMM44 Antibody". www.genecards.org. Retrieved 2018-04-23.