U12 minor spliceosomal RNA
|U12 minor spliceosomal RNA|
|Predicted secondary structure and sequence conservation of U12|
|RNA type||Gene; snRNA; splicing|
|GO||0000371 0045131 0005693|
U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous. The predicted secondary structure of U12 RNA is published, but the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences. The sequences U12 introns that are spliced out are collected in a biological database called the U12 intron database.
- Tarn, WY; Steitz JA (1997). "Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge". Trends Biochem Sci. 22 (4): 132–137. doi:10.1016/S0968-0004(97)01018-9. PMID 9149533.
- Shukla, GC; Padgett RA (1999). "Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants". RNA. 5 (4): 525–538. doi:10.1017/S1355838299982213. PMC . PMID 10199569.
- Otake, LR; Scamborova P; Hashimoto C; Steitz JA (2002). "The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila". Mol Cell. 9 (2): 439–446. doi:10.1016/S1097-2765(02)00441-0. PMID 11864616.
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