UPF3A

UPF3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L08
Identifiers
Aliases	UPF3A, HRENT3A, UPF3, UPF3 regulator of nonsense transcripts homolog A (yeast), regulator of nonsense mediated mRNA decay
External IDs	OMIM: 605530; MGI: 1914281; HomoloGene: 23395; GeneCards: UPF3A; OMA:UPF3A - orthologs
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	13,849,193 bp
RNA expression pattern
	n/a
	Top expressed in
	seminiferous tubule; ; otolith organ; ; utricle; ; Paneth cell; ; fossa; ; trigeminal ganglion; ; condyle; ; medullary collecting duct; ; renal corpuscle; ; hair follicle;
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; telomeric DNA binding; RNA binding; nucleic acid binding; structural constituent of nuclear pore;
Cellular component	exon-exon junction complex; intracellular membrane-bounded organelle; nucleus; cytoplasm; cytosol; nucleolus;
Biological process	mRNA transport; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of translation; nucleocytoplasmic transport;
	Sources:Amigo / QuickGO
Orthologs
	65110
	67031
	ENSG00000169062
	ENSMUSG00000038398
	Q9H1J1
	Q3ULJ3
	NM_023011; NM_080687
	NM_025924
NP_075387; NP_542418; NP_001340573; NP_001340574; NP_001340575;
	NP_001340576; NP_001340577; NP_001340578; NP_001340579; NP_001340580; NP_001340581
	NP_080200
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of nonsense transcripts 3A is a protein that in humans is encoded by the UPF3A gene.^[4]^[5]^[6]

Template:PBB Summary

Interactions

UPF3A has been shown to interact with RBM8A,^[7] UPF2^[5]^[8] and UPF1.^[5]^[9]^[10]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038398 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE (January 2001). "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)". Mol Cell Biol. 21 (1): 209–23. doi:10.1128/MCB.21.1.209-223.2001. PMC 88795. PMID 11113196.
^ ^a ^b ^c Lykke-Andersen J, Shu MD, Steitz JA (February 2001). "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon". Cell. 103 (7): 1121–31. doi:10.1016/S0092-8674(00)00214-2. PMID 11163187.
^ "Entrez Gene: UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)".
^ Kim, V N; Kataoka N; Dreyfuss G (September 2001). "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex". Science. 293 (5536). United States: 1832–6. Bibcode:2001Sci...293.1832K. doi:10.1126/science.1062829. ISSN 0036-8075. PMID 11546873. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
^ Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3). United States: 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
^ Schell, Thomas; Köcher Thomas; Wilm Matthias; Seraphin Bertrand; Kulozik Andreas E; Hentze Matthias W (August 2003). "Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells". Biochem. J. 373 (Pt 3). England: 775–83. doi:10.1042/BJ20021920. ISSN 0264-6021. PMC 1223536. PMID 12723973. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Yamashita, A; Ohnishi T; Kashima I; Taya Y; Ohno S (September 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17). United States: 2215–28. doi:10.1101/gad.913001. ISSN 0890-9369. PMC 312771. PMID 11544179. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading