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Role in DNA repair[edit]

Since DNA polymerase delta is involved in resynthesis of excised damaged DNA strands during DNA repair, PCNA is important for both DNA synthesis and DNA repair[1]. PCNA is also involved in the switch to DNA damage bypass translesion synthesis:

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PCNA-binding proteins[edit]

DNA polymerases  • Clamp loader  • Flap endonuclease  • DNA ligase  • Topoisomerase  • Replication licensing factor  • E3 ubiquitin ligases  • E2 SUMO-conjugating enzyme  • Helicases, ATPases  • Mismatch repair enzymes  • Base excision repair enzymes  • Nucleotide excision repair enzyme  • Poly ADP ribose polymerase  • Histone chaperone  • Chromatin remodeling factor  • Histone acetyltransferase  • Histone deacetyltransferase  • DNA methyltransferase  • Sister-chromatid cohesion factors  • Protein kinases  • Cell-cycle regulators  • Apoptotic factors

for details see [2]

See also[edit]

External links[edit]

References[edit]

  1. ^ J. Essers, A. F. Theil, C. Baldeyron, W. A. van Cappellen, A. B. Houtsmuller, R. Kanaar and W. Vermeulen (2005) "Nuclear dynamics of PCNA in DNA replication and repair" Molecular and Cellular Biology Volume 25, pages 9350-9359. PMID 16227586
  2. ^ Moldovan GL, Pfander B, Jentsch S (2007). "PCNA, the maestro of the replication fork". Cell. 129 (4): 665–79. doi:10.1016/j.cell.2007.05.003. PMID 17512402.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ G. D. Bowman, M. O'Donnell and J. Kuriyan (2004) "Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex" in Nature Volume 429, pages 724-730. PMID 15201901
  4. ^ T.Miyata, H. Suzuki, T. Oyama, K. Mayanagi, Y.Ishino and K. Morikawa (2005) "Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis" in Proceedings of the National Academy of Sciences of the United States of America Volume 102, pages 13795-13800.PMID 16169902

Further reading[edit]

  • Prosperi E (1998). "Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control". Progress in cell cycle research. 3: 193–210. PMID 9552415.
  • Miura M (1999). "Detection of chromatin-bound PCNA in mammalian cells and its use to study DNA excision repair". J. Radiat. Res. 40 (1): 1–12. PMID 10408173.
  • Chen M, Pan ZQ, Hurwitz J (1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2516–20. PMID 1313560.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Kemeny MM, Alava G, Oliver JM (1993). "Improving responses in hepatomas with circadian-patterned hepatic artery infusions of recombinant interleukin-2". J. Immunother. 12 (4): 219–23. PMID 1477073.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Morris GF, Mathews MB (1990). "Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1". J. Biol. Chem. 265 (27): 16116–25. PMID 1975809.
  • Webb G, Parsons P, Chenevix-Trench G (1991). "Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization". Hum. Genet. 86 (1): 84–6. PMID 1979311.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Travali S, Ku DH, Rizzo MG; et al. (1989). "Structure of the human gene for the proliferating cell nuclear antigen". J. Biol. Chem. 264 (13): 7466–72. PMID 2565339. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Ku DH, Travali S, Calabretta B; et al. (1989). "Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20". Somat. Cell Mol. Genet. 15 (4): 297–307. PMID 2569765. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Prelich G, Kostura M, Marshak DR; et al. (1987). "The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro". Nature. 326 (6112): 471–5. doi:10.1038/326471a0. PMID 2882422. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Almendral JM, Huebsch D, Blundell PA; et al. (1987). "Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins". Proc. Natl. Acad. Sci. U.S.A. 84 (6): 1575–9. PMID 2882507. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Chen IT, Smith ML, O'Connor PM, Fornace AJ (1995). "Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA". Oncogene. 11 (10): 1931–7. PMID 7478510.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Li X, Li J, Harrington J; et al. (1995). "Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen". J. Biol. Chem. 270 (38): 22109–12. PMID 7673186. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Fukuda K, Morioka H, Imajou S; et al. (1995). "Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen". J. Biol. Chem. 270 (38): 22527–34. PMID 7673244. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Warbrick E, Lane DP, Glover DM, Cox LS (1995). "A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen". Curr. Biol. 5 (3): 275–82. PMID 7780738.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Hall PA, Kearsey JM, Coates PJ; et al. (1995). "Characterisation of the interaction between PCNA and Gadd45". Oncogene. 10 (12): 2427–33. PMID 7784094. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID 7821789. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Matsuoka S, Yamaguchi M, Matsukage A (1994). "D-type cyclin-binding regions of proliferating cell nuclear antigen". J. Biol. Chem. 269 (15): 11030–6. PMID 7908906.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Szepesi A, Gelfand EW, Lucas JJ (1994). "Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes". Blood. 84 (10): 3413–21. PMID 7949095.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Smith ML, Chen IT, Zhan Q; et al. (1994). "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen". Science. 266 (5189): 1376–80. PMID 7973727. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Pan ZQ, Chen M, Hurwitz J (1993). "The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis". Proc. Natl. Acad. Sci. U.S.A. 90 (1): 6–10. PMID 8093561.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links[edit]

[[Category:DNA replication]] [[Category:DNA repair]] [[Category:Proteins]] [[de:PCNA]] [[fr:Proliferating Cell Nuclear Antigen]] [[uk:Ядерний антиген проліферуючих клітин]]

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