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VNN1

From Wikipedia, the free encyclopedia
VNN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVNN1, HDLCQ8, Tiff66, vanin 1
External IDsMGI: 108395; HomoloGene: 32130; GeneCards: VNN1; OMA:VNN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004666

NM_011704

RefSeq (protein)

NP_004657

NP_035834

Location (UCSC)Chr 6: 132.68 – 132.71 MbChr 10: 23.77 – 23.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene.[5][6]

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112299Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037440Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.
  6. ^ a b "Entrez Gene: VNN1 vanin 1".

Further reading

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