VPRBP

DCAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WA0, 4CC9, 4P7I, 4PXW, 4Z8L, 5AJA
Identifiers
Aliases	DCAF1, VPRBP, Vpr (HIV-1) binding protein, DDB1 and CUL4 associated factor 1, RIP
External IDs	OMIM: 617259; MGI: 2445220; HomoloGene: 8805; GeneCards: DCAF1; OMA:DCAF1 - orthologs
EC number	2.7.11.1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	51,500,015 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	106,758,191 bp
RNA expression pattern
	Top expressed in
	sperm; ; right testis; ; left testis; ; pericardium; ; tendon of biceps brachii; ; vena cava; ; ventricular zone; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; ganglionic eminence;
	Top expressed in
	genital tubercle; ; tail of embryo; ; zygote; ; spermatid; ; secondary oocyte; ; spermatocyte; ; CA3 field; ; lactiferous gland; ; entorhinal cortex; ; perirhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; histone kinase activity (H2A-T120 specific); protein serine/threonine kinase activity; protein binding; ATP binding; estrogen receptor binding;
Cellular component	cytoplasm; COP9 signalosome; nucleus; fibrillar center; Cul4-RING E3 ubiquitin ligase complex;
Biological process	regulation of transcription, DNA-templated; phosphorylation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; cell competition in a multicellular organism; protein ubiquitination; V(D)J recombination; B cell differentiation; viral process; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	9730
	321006
	ENSG00000145041
	ENSMUSG00000040325
	Q9Y4B6
	Q80TR8
NM_001171904; NM_014703; NM_001349168; NM_001349169; NM_001349170;
	NM_001349171; NM_001387578; NM_001387579; NM_001387580; NM_001387581; NM_001387582; NM_001387583
	NM_001015507; NM_001373930; NM_001373931
NP_001165375; NP_055518; NP_001336097; NP_001336098; NP_001336099;
	NP_001336100
	NP_001015507; NP_001360859; NP_001360860
	Wikidata
View/Edit Human	View/Edit Mouse

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

VPRBP has been shown to interact with Merlin.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145041 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040325 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhao LJ, Mukherjee S, Narayan O (Jun 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". J Biol Chem. 269 (22): 15577–82. PMID 8195203.
^ Zhang S, Feng Y, Narayan O, Zhao LJ (Mar 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene. 263 (1–2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.
^ "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".
^ Huang, J; Chen J (Jul 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29). England: 4056–64. doi:10.1038/onc.2008.44. PMID 18332868. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)

Interactions

References

Further reading