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Protein VPS4A PDB 1yxr.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesVPS4A, SKD1, SKD1A, SKD2, VPS4, VPS4-1, vacuolar protein sorting 4 homolog A
External IDsOMIM: 609982 MGI: 1890520 HomoloGene: 69132 GeneCards: VPS4A
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for VPS4A
Genomic location for VPS4A
Band16q22.1Start69,311,350 bp[1]
End69,326,939 bp[1]
RNA expression pattern
PBB GE VPS4A 217913 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 16: 69.31 – 69.33 MbChr 8: 107.03 – 107.05 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.[5][6][7]


The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.[7]


VPS4A has been shown to interact with CHMP1A.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132612 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031913 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bishop N, Woodman P (April 2000). "ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking". Mol Biol Cell. 11 (1): 227–39. doi:10.1091/mbc.11.1.227. PMC 14770. PMID 10637304.
  6. ^ Scheuring S, Röhricht RA, Schöning-Burkhardt B, Beyer A, Müller S, Abts HF, Köhrer K (September 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
  7. ^ a b "Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)".
  8. ^ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (July 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell Sci. 114 (Pt 13): 2395–404. PMID 11559748.

Further reading[edit]