Velaglucerase alfa

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Velaglucerase alfa
Clinical data
Routes of
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability N/A
Biological half-life Plasma: 5–12 minutes (absorbed by macrophages)
  • none
Chemical and physical data
Formula C2532H3850N672O711S16
Molar mass 55.5 kg/mol (unglycosylated)
 NYesY (what is this?)  (verify)

Velaglucerase alfa (trade name VPRIV), manufactured by Shire plc is a hydrolytic lysosomal glucocerebroside-specific enzyme, which is a recombinant form of glucocerebrosidase indicated as a long-term enzyme replacement therapy for those suffering of Gaucher disease Type 1. It has an identical amino acid sequence to the naturally occurring enzyme.[1] It was approved for use by the U.S. Food and Drug Administration (FDA) on February 26, 2010.[2]

Competitive products[edit]

Imiglucerase is Genzyme's version of recombinant glucocerebrosidase. It is marketed globally under the trade name of Cerezyme.

In addition, Protalix and Pfizer have received approval for marketing taliglucerase alpha in Israel, Brazil, Canada and the U.S. The companies are expected also to file for marketing authorization in Europe and elsewhere around the world.