Secobarbital/brallobarbital/hydroxyzine
| Combination of | |
|---|---|
| Brallobarbital | barbiturate |
| Secobarbital | barbiturate |
| Hydroxyzine | antihistamine |
| Clinical data | |
| Trade names | Vesparax |
Vesparax is a combination tablet containing 50 mg brallobarbital, 150 mg secobarbital and 50 mg hydroxyzine[1] that is used as a sedative. This drug has been withdrawn from the market in most countries.
Hydroxyzine and secobarbital lengthen the half-life of brallobarbital. Because of the long half-life of Vesparax, it has symptoms resembling a hangover on the next day,[2] and it has been replaced by newer medicine.[3]
Jimi Hendrix was under the influence of Vesparax when he died of asphyxia due to aspiration of vomit on September 18th, 1970.[4]
In Argentina, Vesparax is a trade name for quetiapine, an atypical antipsychotic.[5]
References
- ^ Lhermann J. Clinical application of a new very active hypnotic associating sodium secobarbital, calcium brallobarbital and hydroxyzine (UC-8130). Gazette Medicale de France. 1964 Mar 10;71:961-2. (French)
- ^ Yih TD, Rossum JM. Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication. Xenobiotica. 1976 Jun;6(6):355-62.
- ^ Fischbach R. Efficacy and safety of midazolam and vesparax in treatment of sleep disorders. British Journal of Clinical Pharmacology. 1983;16 Suppl 1:167S-171S.
- ^ Brown, Tony (1997). Jimi Hendrix: The Final Days. Omnibus Press. ISBN 978-0-7119-5238-6.
- ^ "VESPARAX® (quetiapina) comprimidos recubiertos, Prospecto del producto", Dr. Lazar y Cía. S.A.Q. e I.. Fecha revisión del prospecto: 27/1/2005. (in Spanish) [1]