WASF2

WASF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A40
Identifiers
Aliases	WASF2, IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2, WAS protein family member 2, WASP family member 2
External IDs	OMIM: 605875; MGI: 1098641; HomoloGene: 86743; GeneCards: WASF2; OMA:WASF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,490,167 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,927,067 bp
RNA expression pattern
	Top expressed in
	nipple; ; skin of arm; ; tendon of biceps brachii; ; saphenous vein; ; pylorus; ; lower lobe of lung; ; cardia; ; mucosa of pharynx; ; trachea; ; lactiferous duct;
	Top expressed in
	zygote; ; left lung lobe; ; tibiofemoral joint; ; secondary oocyte; ; vas deferens; ; gastrula; ; Gonadal ridge; ; mesenteric lymph nodes; ; submandibular gland; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein binding; actin binding; SH3 domain binding; cadherin binding; protein kinase A binding;
Cellular component	cytoplasm; cytosol; cell projection; SCAR complex; cell-cell junction; ruffle; intracellular anatomical structure; early endosome; actin cytoskeleton; extracellular exosome; cytoskeleton; lamellipodium; protein-containing complex; synapse;
Biological process	megakaryocyte development; endocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; actin filament-based movement; vascular endothelial growth factor receptor signaling pathway; angiogenesis; Rac protein signal transduction; viral process; positive regulation of lamellipodium assembly; negative regulation of stress fiber assembly; ameboidal-type cell migration; lamellipodium morphogenesis; actin cytoskeleton organization; lamellipodium assembly; postsynaptic actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	10163
	242687
	ENSG00000158195
	ENSMUSG00000028868
	Q9Y6W5
	Q8BH43
	NM_006990; NM_001201404
	NM_153423
	NP_001188333; NP_008921
	NP_700472
	Wikidata
View/Edit Human	View/Edit Mouse

Wiskott-Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.^[5]

Template:PBB Summary

Interactions

WASF2 has been shown to interact with BAIAP2.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158195 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028868 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Suetsugu S, Miki H, Takenawa T (July 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem Biophys Res Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
^ Miki, H; Yamaguchi H; Suetsugu S; Takenawa T (December 2000). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature. 408 (6813). England: 732–5. doi:10.1038/35047107. ISSN 0028-0836. PMID 11130076. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

External links

WASF2 human gene location in the UCSC Genome Browser.
WASF2 human gene details in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158195 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028868 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10381382-5] Suetsugu S, Miki H, Takenawa T (July 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem Biophys Res Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.

[pmid11130076-6] Miki, H; Yamaguchi H; Suetsugu S; Takenawa T (December 2000). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature. 408 (6813). England: 732–5. doi:10.1038/35047107. ISSN 0028-0836. PMID 11130076. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

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Interactions

References

Further reading

External links