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WDR1

From Wikipedia, the free encyclopedia
WDR1
Identifiers
AliasesWDR1, AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS
External IDsOMIM: 604734; MGI: 1337100; HomoloGene: 6628; GeneCards: WDR1; OMA:WDR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005112
NM_017491

NM_011715

RefSeq (protein)

NP_005103
NP_059830

NP_035845

Location (UCSC)Chr 4: 10.07 – 10.12 MbChr 5: 38.68 – 38.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.[5][6]

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000071127Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005103Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics. 56 (1): 59–69. doi:10.1006/geno.1998.5672. PMID 10036186.
  6. ^ a b "Entrez Gene: WDR1 WD repeat domain 1".

Further reading

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