WFDC1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
WFDC1
Identifiers
Aliases WFDC1, PS20, WAP four-disulfide core domain 1
External IDs MGI: 1915116 HomoloGene: 10920 GeneCards: WFDC1
RNA expression pattern
PBB GE WFDC1 219478 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282466
NM_001282467
NM_021197

NM_023395

RefSeq (protein)

NP_001269395
NP_001269396
NP_067020

NP_075884.1
NP_075884

Location (UCSC) Chr 16: 84.29 – 84.33 Mb Chr 8: 119.67 – 119.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene.[3][4]

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, Rowley DR (Sep 2000). "The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers". Mamm Genome. 11 (9): 767–73. doi:10.1007/s003350010135. PMID 10967136. 
  4. ^ a b "Entrez Gene: WFDC1 WAP four-disulfide core domain 1". 

Further reading[edit]