WFIKKN1

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WFIKKN1
Protein WFIKKN1 PDB 2ddi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases WFIKKN1, C16orf12, RJD2, WFDC20A, WFIKKN, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
External IDs MGI: 2670967 HomoloGene: 14244 GeneCards: WFIKKN1
RNA expression pattern
PBB GE WFIKKN1 gnf1h01263 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_053284

NM_001100454

RefSeq (protein)

NP_444514

NP_001093924.1
NP_001093924

Location (UCSC) Chr 16: 0.63 – 0.63 Mb Chr 17: 25.88 – 25.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.[3][4][5] when found in humans.

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A. 98 (7): 3705–9. doi:10.1073/pnas.061028398. PMC 31116Freely accessible. PMID 11274388. 
  4. ^ Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. 
  5. ^ a b "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1". 

Further reading[edit]