WFIKKN1

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
WFIKKN1
Protein WFIKKN1 PDB 2ddi.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWFIKKN1, C16orf12, RJD2, WFDC20A, WFIKKN, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
External IDsOMIM: 608021 MGI: 2670967 HomoloGene: 14244 GeneCards: WFIKKN1
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for WFIKKN1
Genomic location for WFIKKN1
Band16p13.3Start629,239 bp[1]
End634,117 bp[1]
RNA expression pattern
PBB GE WFIKKN1 gnf1h01263 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_053284

NM_001100454

RefSeq (protein)

NP_444514

NP_001093924

Location (UCSC)Chr 16: 0.63 – 0.63 MbChr 17: 25.88 – 25.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.[5][6][7] when found in humans.

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127578 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071192 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A. 98 (7): 3705–9. doi:10.1073/pnas.061028398. PMC 31116. PMID 11274388.
  6. ^ Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817.
  7. ^ a b "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1".

Further reading[edit]