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WNK2

From Wikipedia, the free encyclopedia
WNK2
Identifiers
AliasesWNK2, NY-CO-43, P/OKcl.13, PRKSDCCAG43, WNK lysine deficient protein kinase 2
External IDsOMIM: 606249; MGI: 1922857; HomoloGene: 19155; GeneCards: WNK2; OMA:WNK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282394
NM_006648

NM_001290311
NM_001290313
NM_029361

RefSeq (protein)

NP_001269323
NP_006639

NP_001277240
NP_001277242
NP_083637

Location (UCSC)Chr 9: 93.18 – 93.32 MbChr 13: 49.19 – 49.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase WNK2 is an enzyme that in humans is encoded by the WNK2 gene.[5][6][7]

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165238Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037989Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
  6. ^ Verissimo F, Jordan P (Sep 2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene. 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
  7. ^ a b "Entrez Gene: WNK2 WNK lysine deficient protein kinase 2".

Further reading

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