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WRNIP1

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WRNIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWRNIP1, WHIP, bA420G6.2, Werner helicase interacting protein 1, WRN helicase interacting protein 1, CFAP93, FAP93
External IDsOMIM: 608196; MGI: 1926153; HomoloGene: 10592; GeneCards: WRNIP1; OMA:WRNIP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020135
NM_130395

NM_030215

RefSeq (protein)

NP_064520
NP_569079

NP_084491

Location (UCSC)Chr 6: 2.77 – 2.79 MbChr 13: 32.99 – 33.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATPase WRNIP1 is an enzyme that is encoded by the WRNIP1 gene in humans.[5][6] The protein is a member of AAA ATPase family.

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.[6]

Interactions

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WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124535Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021400Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T (Jun 2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem. 276 (23): 20364–9. doi:10.1074/jbc.C100035200. PMID 11301316.
  6. ^ a b "Entrez Gene: WRNIP1 Werner helicase interacting protein 1".

Further reading

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