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WW domain containing E3 ubiquitin protein ligase 1
Protein WWP1 PDB 1nd7.png
PDB rendering based on 1nd7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols WWP1 ; AIP5; Tiul1; hSDRP1
External IDs OMIM602307 HomoloGene21385 GeneCards: WWP1 Gene
RNA expression pattern
PBB GE WWP1 212637 s at tn.png
PBB GE WWP1 212638 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11059 107568
Ensembl ENSG00000123124 ENSMUSG00000041058
UniProt Q9H0M0 Q8BZZ3
RefSeq (mRNA) NM_007013 NM_001276292
RefSeq (protein) NP_008944 NP_001263221
Location (UCSC) Chr 8:
86.34 – 86.48 Mb
Chr 4:
19.61 – 19.71 Mb
PubMed search [1] [2]

NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.[1][2][3]


WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.[3]


WWP1 has been shown to interact with:


  1. ^ Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (June 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J Biol Chem 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421. 
  2. ^ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (July 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol Cell Neurosci 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693. 
  3. ^ a b "Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1". 
  4. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ Conkright MD, Wani MA, Lingrel JB (August 2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995. 
  6. ^ Qin H, Pu HX, Li M, Ahmed S, Song J (Dec 2008). "Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration". Biochemistry 47 (51): 13647–58. doi:10.1021/bi8017976. PMID 19035836. 

Further reading[edit]