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WW domain containing E3 ubiquitin protein ligase 1
Protein WWP1 PDB 1nd7.png
PDB rendering based on 1nd7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols WWP1 ; AIP5; Tiul1; hSDRP1
External IDs OMIM602307 HomoloGene21385 GeneCards: WWP1 Gene
RNA expression pattern
PBB GE WWP1 212637 s at tn.png
PBB GE WWP1 212638 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11059 107568
Ensembl ENSG00000123124 ENSMUSG00000041058
UniProt Q9H0M0 Q8BZZ3
RefSeq (mRNA) NM_007013 NM_001276292
RefSeq (protein) NP_008944 NP_001263221
Location (UCSC) Chr 8:
87.35 – 87.49 Mb
Chr 4:
19.61 – 19.71 Mb
PubMed search [1] [2]

NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.[1][2][3]


WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.[3]


WWP1 has been shown to interact with:


  1. ^ Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK et al. (June 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J Biol Chem 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421. 
  2. ^ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J et al. (July 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol Cell Neurosci 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693. 
  3. ^ a b "Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1". 
  4. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ Conkright MD, Wani MA, Lingrel JB (August 2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995. 
  6. ^ Qin H, Pu HX, Li M, Ahmed S, Song J (Dec 2008). "Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration". Biochemistry 47 (51): 13647–58. doi:10.1021/bi8017976. PMID 19035836. 

Further reading[edit]