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Melanoma[edit]

It's been Medicine Collaboration of the Week, and has improved a lot. We'd like to hear comments about it. Thanks! NCurse work 15:30, 12 August 2006 (UTC)[reply]

  • The lead is a little short - seems like it should include diagnostic methods and prevalence info at least. Also, the mention of resection before 1mm - I assume that's a statistical association, but it sounds rather arbitrary and probably needs a citation.
  • Only one question: the first sentence says melanoma is a malignant tumor, but later in the lead there's a mention of "premalignant" melanoma. Is it necessarily malignant, and if so, is there a separate term for the early stages? Opabinia regalis 15:43, 13 August 2006 (UTC)[reply]
  • Many sections are quite listy. The staging section obviously should be a list, but even some of the prose sections - History and Epidemiology especially - read like a series of only somewhat related sentences rather than a coherent story. This may be because research hasn't told a very coherent story yet, but it should still be synthesized more clearly if possible. "Prevention" should definitely be prose, except the "mnemonic" (where did that come from anyway?)
  • The ABCDE mnemonic comes from the Asymmetrical, Border, Color, Diameter, Evolution words. But the sections says "(see "ABCDE" mnemonic below.)" because in the list below these letters are bold too. NCurse work 08:33, 13 August 2006 (UTC)[reply]
  • I think epidemiology looks pretty good. On second glance my only real problem with the history section is the first sentence: "While there is little serious doubt that melanoma is not a relatively new disease..." is just too many double negatives and qualifiers in one place. Is there any serious doubt? Opabinia regalis 20:32, 13 August 2006 (UTC)[reply]
  • No, it is NOT a new disease, just we weren't so brave to write it like that. But I removed relatively and inserted a reference (which can't be found on the net, it's from 1966) - On the antiquity of melanoma. NCurse work 07:08, 14 August 2006 (UTC)[reply]
  • To be honest, I really can't see why do we need this primary-secondary section names, without these the prevention section would be total too. Anyway I can put avoidance and vigilance next to the primary and secondary words. NCurse work 20:56, 13 August 2006 (UTC)[reply]
  • Are "avoidance" and "vigilance" really good restatements of the meanings? That was my guess from the context, but I'm sure you're more knowledgeable about medical usage than I am. I'd agree that the distinction isn't critical to the section's flow. Opabinia regalis 04:46, 14 August 2006 (UTC)[reply]
  • Is there a more dramatic image than Image:WB032021.JPG? Or maybe just touch up the color on this one?
  • There's a lot of emphasis on sun damage and sunburn as risk factors, but most people have had a peeling sunburn at some point in their lives - maybe flesh out the statistics on this, or find some relative-risk data?
  • I found a reference for this sentence: "Occasional extreme sun exposure (resulting in "sunburn") is causally related to melanoma." The reference is a study: Sun exposure and risk of melanoma. Hope it will be enough. :) NCurse work 18:32, 13 August 2006 (UTC)[reply]
  • My concern here is that someone's going to read the article and think "Holy crap! I had a sunburn once; now I'm going to get skin cancer and die!" Is there some data to the effect of "x level of exposure to UV radiation increases melanoma risk by y%"?
  • Most of the article is well-referenced, but there's a few statements in the epidemiology section especially that don't have citations - like the "Australia" data and the "British study".
  • The tissue slides are nice but could use a more descriptive caption.
  • "This radiation causes errors in the deoxyribonucleic acid (DNA) of cells, making them go through mitosis (cell division) at an unhealthy rate. " -- Not very clear. I assume the increased mitosis rate thing refers to inappropriate cell division after the tumor has formed, but the sentence implies that radiation damage itself accelerates mitosis rates, which as far as I know is not correct. It should be explicitly stated that radiation damage induces mutations, which can accumulate as cell division proceeds to create inappropriately-dividing cancerous cells.
  • Is the something about melanoma metastases specifically that makes them more difficult to treat? Are they just difficult to detect, or are they more dangerous in some way than metastases from other types of cancers?
  • To me it sounds like the article is saying metastases of melanoma specifically are more deadly than metastases of other cancers. Is that the case? (In either case, it's not critical but it might be interesting to see comparisons in prevalence and survival rates to other common cancers.) Opabinia regalis 15:43, 13 August 2006 (UTC)[reply]

Opabinia regalis 22:26, 12 August 2006 (UTC)[reply]

I've found uploaded 4 images. NCurse work 09:33, 14 August 2006 (UTC)[reply]
  • Some more info on familial melanoma and genetics of melanoma is probably needed. I suppose there has been some recent research in this area that is not fully reflected in the article. Kpjas 18:01, 14 August 2006 (UTC)[reply]
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