|Directed by||George Chesebro
|Written by||Cliff Hill|
Ryan Brothers Productions
|Distributed by||Lee-Bradford Corporation|
|Language||Silent (English intertitles)|
Dick Bannister is the new field boss of the Ford Logging Company, a Canadian logging-crew during a time when conflicts with the powerful Consolidated Lumber Company, a bitter rival company, have turned bloody, like a private war. His boss, Miss Edith Ford, comes to inspect the lumberjack camp, bringing her doctor fiancé with her. Dick is attacked by his rivals and left for dead. His loss of blood is so great that he needs a transfusion, but no human will volunteer, so the surgeon uses a wolf as a source of the blood. Afterwards, Dick begins having dreams where he runs with a pack of phantom wolves, and the rival loggers get killed by wolves. Soon, these facts have spread through the camp and most of the lumberjacks decide that Dick is a werewolf. Bannister, in his attempt to jump off a cliff, is rescued by Edith.
- George Chesebro as Dick Bannister.
- Marguerite Clayton as Miss Edith Ford, owner of the Ford Logging Company.
- Raymond "Ray" Hanford as Dr. Eugene "Gene" Horton, Edith's fiancé.
- Roy Watson as Jules Deveroux, envious owner of the Consolidated Lumber Company.
- Milburn Morante as Jacques Lebeq, notorious bootlegger.
- Frank Clark as Old Pop Hadley, alcoholic woods guard for the Ford Logging Company.
- Jack Cosgrave as Edith's uncle and manager.
The film has been referenced in a number of books as being the first werewolf movie ever made. This however is erroneous; the first werewolf movie is The Werewolf, a film made in 1913. However this film is considered to be lost. Therefore Wolf Blood should rather be called the earliest surviving werewolf film.