XPO5

XPO5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A6P
Identifiers
Aliases	XPO5, exp5, exportin 5
External IDs	OMIM: 607845 MGI: 1913789 HomoloGene: 69316 GeneCards: XPO5
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,576,038 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,554,524 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; ganglionic eminence; ; bone marrow cells; ; right lobe of thyroid gland; ; skin of abdomen; ; islet of Langerhans; ; left lobe of thyroid gland; ; metanephros; ; stromal cell of endometrium; ; anterior pituitary;
	Top expressed in
	gallbladder; ; superior surface of tongue; ; maxillary prominence; ; interventricular septum; ; spermatocyte; ; adrenal gland; ; ganglionic eminence; ; abdominal wall; ; spermatid; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tRNA binding; mRNA binding; protein binding; RNA binding; nuclear export signal receptor activity; pre-miRNA binding;
Cellular component	cytoplasm; RNA nuclear export complex; nucleus; nucleoplasm; cytosol; nuclear RNA export factor complex;
Biological process	protein export from nucleus; positive regulation of RNA interference; protein transport; intracellular protein transport; miRNA metabolic process; gene silencing; regulation of protein export from nucleus; pre-miRNA export from nucleus; transport; nuclear export;
	Sources:Amigo / QuickGO
Orthologs
	57510
	72322
	ENSG00000124571
	ENSMUSG00000067150
	Q9HAV4
	Q924C1
	NM_020750
	NM_028198
	NP_065801
	NP_082474
	Wikidata
View/Edit Human	View/Edit Mouse

Exportin-5 (XPO5) is a protein that in humans is encoded by the XPO5 gene.^[5]^[6]^[7]

Exportin-5 is a member of the karyopherin family.^[7] In metazoa, it is involved in transport of pre-microRNA out of the nucleus, where such molecules are generated by the Microprocessor complex, and into the cytoplasm for further processing by the Dicer enzyme.^[8]^[9]^[10]^[11]

The plant homolog is called HASTY; although it is known to be required for the miRNA biogenesis pathway, its role in nuclear export is less clear than it is in animals.^[12]

Interactions

XPO5 has been shown to interact with ILF3^[5] and Ran.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124571 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067150 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Brownawell AM, Macara IG (Jan 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". The Journal of Cell Biology. 156 (1): 53–64. doi:10.1083/jcb.200110082. PMC 2173575. PMID 11777942.
^ Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D (Nov 2002). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". The EMBO Journal. 21 (22): 6205–15. doi:10.1093/emboj/cdf613. PMC 137205. PMID 12426392.
^ ^a ^b "Entrez Gene: XPO5 exportin 5".
^ Yi R, Qin Y, Macara IG, Cullen BR (Dec 2003). "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs". Genes & Development. 17 (24): 3011–6. doi:10.1101/gad.1158803. PMC 305252. PMID 14681208.
^ Wilson RC, Doudna JA (2013). "Molecular mechanisms of RNA interference". Annual Review of Biophysics. 42: 217–39. doi:10.1146/annurev-biophys-083012-130404. PMID 23654304.
^ Siomi H, Siomi MC (May 2010). "Posttranscriptional regulation of microRNA biogenesis in animals". Molecular Cell. 38 (3): 323–32. doi:10.1016/j.molcel.2010.03.013. PMID 20471939.
^ Macias S, Cordiner RA, Cáceres JF (Aug 2013). "Cellular functions of the microprocessor". Biochemical Society Transactions. 41 (4): 838–43. doi:10.1042/BST20130011. PMID 23863141.
^ Voinnet O (Feb 2009). "Origin, biogenesis, and activity of plant microRNAs". Cell. 136 (4): 669–87. doi:10.1016/j.cell.2009.01.046. PMID 19239888.

Calado A, Treichel N, Müller EC, Otto A, Kutay U (Nov 2002). "Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA". The EMBO Journal. 21 (22): 6216–24. doi:10.1093/emboj/cdf620. PMC 137209. PMID 12426393.
Gwizdek C, Ossareh-Nazari B, Brownawell AM, Doglio A, Bertrand E, Macara IG, Dargemont C (Feb 2003). "Exportin-5 mediates nuclear export of minihelix-containing RNAs". The Journal of Biological Chemistry. 278 (8): 5505–8. doi:10.1074/jbc.C200668200. PMID 12509441.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Gwizdek C, Ossareh-Nazari B, Brownawell AM, Evers S, Macara IG, Dargemont C (Jan 2004). "Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3". The Journal of Biological Chemistry. 279 (2): 884–91. doi:10.1074/jbc.M306808200. PMID 14570900.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Lund E, Güttinger S, Calado A, Dahlberg JE, Kutay U (Jan 2004). "Nuclear export of microRNA precursors". Science. 303 (5654): 95–8. doi:10.1126/science.1090599. PMID 14631048.
Bohnsack MT, Czaplinski K, Gorlich D (Feb 2004). "Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs". RNA. 10 (2): 185–91. doi:10.1261/rna.5167604. PMC 1370530. PMID 14730017.
Chen T, Brownawell AM, Macara IG (Aug 2004). "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5". Molecular and Cellular Biology. 24 (15): 6608–19. doi:10.1128/MCB.24.15.6608-6619.2004. PMC 444848. PMID 15254228.
Yi R, Doehle BP, Qin Y, Macara IG, Cullen BR (Feb 2005). "Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs". RNA. 11 (2): 220–6. doi:10.1261/rna.7233305. PMC 1370710. PMID 15613540.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124571 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067150 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11777942-5] Brownawell AM, Macara IG (Jan 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". The Journal of Cell Biology. 156 (1): 53–64. doi:10.1083/jcb.200110082. PMC 2173575. PMID 11777942.

[pmid12426392-6] Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D (Nov 2002). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". The EMBO Journal. 21 (22): 6205–15. doi:10.1093/emboj/cdf613. PMC 137205. PMID 12426392.

[entrez-7] "Entrez Gene: XPO5 exportin 5".

[yi-8] Yi R, Qin Y, Macara IG, Cullen BR (Dec 2003). "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs". Genes & Development. 17 (24): 3011–6. doi:10.1101/gad.1158803. PMC 305252. PMID 14681208.

[wilson-9] Wilson RC, Doudna JA (2013). "Molecular mechanisms of RNA interference". Annual Review of Biophysics. 42: 217–39. doi:10.1146/annurev-biophys-083012-130404. PMID 23654304.

[siomi-10] Siomi H, Siomi MC (May 2010). "Posttranscriptional regulation of microRNA biogenesis in animals". Molecular Cell. 38 (3): 323–32. doi:10.1016/j.molcel.2010.03.013. PMID 20471939.

[macias-11] Macias S, Cordiner RA, Cáceres JF (Aug 2013). "Cellular functions of the microprocessor". Biochemical Society Transactions. 41 (4): 838–43. doi:10.1042/BST20130011. PMID 23863141.

[voinnet-12] Voinnet O (Feb 2009). "Origin, biogenesis, and activity of plant microRNAs". Cell. 136 (4): 669–87. doi:10.1016/j.cell.2009.01.046. PMID 19239888.

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Interactions

References

Further reading