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Available structures
PDB Ortholog search: PDBe RCSB
Aliases XPO5, exp5, exportin 5
External IDs MGI: 1913789 HomoloGene: 69316 GeneCards: XPO5
RNA expression pattern
PBB GE XPO5 gnf1h05645 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 43.52 – 43.58 Mb Chr 17: 46.2 – 46.24 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Exportin-5 (XPO5) is a protein that in humans is encoded by the XPO5 gene.[3][4][5]

Exportin-5 is a member of the karyopherin family.[5] In metazoa, it is involved in transport of pre-microRNA out of the nucleus, where such molecules are generated by the Microprocessor complex, and into the cytoplasm for further processing by the Dicer enzyme.[6][7][8][9]

The plant homolog is called HASTY; although it is known to be required for the miRNA biogenesis pathway, its role in nuclear export is less clear than it is in animals.[10]


XPO5 has been shown to interact with ILF3[3] and Ran.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c Brownawell AM, Macara IG (Jan 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". The Journal of Cell Biology. 156 (1): 53–64. doi:10.1083/jcb.200110082. PMC 2173575Freely accessible. PMID 11777942. 
  4. ^ Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D (Nov 2002). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". The EMBO Journal. 21 (22): 6205–15. doi:10.1093/emboj/cdf613. PMC 137205Freely accessible. PMID 12426392. 
  5. ^ a b "Entrez Gene: XPO5 exportin 5". 
  6. ^ Yi R, Qin Y, Macara IG, Cullen BR (Dec 2003). "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs". Genes & Development. 17 (24): 3011–6. doi:10.1101/gad.1158803. PMC 305252Freely accessible. PMID 14681208. 
  7. ^ Wilson RC, Doudna JA (2013). "Molecular mechanisms of RNA interference". Annual Review of Biophysics. 42: 217–39. doi:10.1146/annurev-biophys-083012-130404. PMID 23654304. 
  8. ^ Siomi H, Siomi MC (May 2010). "Posttranscriptional regulation of microRNA biogenesis in animals". Molecular Cell. 38 (3): 323–32. doi:10.1016/j.molcel.2010.03.013. PMID 20471939. 
  9. ^ Macias S, Cordiner RA, Cáceres JF (Aug 2013). "Cellular functions of the microprocessor". Biochemical Society Transactions. 41 (4): 838–43. doi:10.1042/BST20130011. PMID 23863141. 
  10. ^ Voinnet O (Feb 2009). "Origin, biogenesis, and activity of plant microRNAs". Cell. 136 (4): 669–87. doi:10.1016/j.cell.2009.01.046. PMID 19239888. 

Further reading[edit]