ZFPM2

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ZFPM2
Identifiers
Aliases ZFPM2, DIH3, FOG2, ZC2HC11B, ZNF89B, hFOG-2, SRXY9, zinc finger protein, FOG family member 2
External IDs MGI: 1334444 HomoloGene: 8008 GeneCards: ZFPM2
RNA expression pattern
PBB GE ZFPM2 219778 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012082

NM_011766

RefSeq (protein)

NP_036214

NP_035896.1
NP_035896

Location (UCSC) Chr 8: 104.59 – 105.8 Mb Chr 15: 40.66 – 41.1 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein ZFPM2 is a protein that in humans is encoded by the ZFPM2 gene.[3][4][5]

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.[5]

Mutations in ZFPM2 cause Congenital Diaphragmatic Hernia .[6]

Interactions[edit]

ZFPM2 has been shown to interact with GATA4,[7] GATA1[8] and CTBP2.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Svensson EC, Tufts RL, Polk CE, Leiden JM (Mar 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc Natl Acad Sci U S A. 96 (3): 956–61. doi:10.1073/pnas.96.3.956. PMC 15332Freely accessible. PMID 9927675. 
  4. ^ a b Holmes M, Turner J, Fox A, Chisholm O, Crossley M, Chong B (Sep 1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J Biol Chem. 274 (33): 23491–8. doi:10.1074/jbc.274.33.23491. PMID 10438528. 
  5. ^ a b "Entrez Gene: ZFPM2 zinc finger protein, multitype 2". 
  6. ^ Brady, P; Van Houdt, J; Callewaert, B; Deprest, J; Devriendt, K; Vermeesch, J. R. (2014). "Exome sequencing identifies ZFPM2 as a cause of familial isolated Congenital Diaphragmatic Hernia and possibly cardiovascular malformations". European Journal of Medical Genetics. 57 (6): 247–52. doi:10.1016/j.ejmg.2014.04.006. PMID 24769157. 
  7. ^ Svensson, E C; Tufts R L; Polk C E; Leiden J M (Feb 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 96 (3): 956–61. doi:10.1073/pnas.96.3.956. ISSN 0027-8424. PMC 15332Freely accessible. PMID 9927675. 
  8. ^ Holmes, M; Turner J; Fox A; Chisholm O; Crossley M; Chong B (Aug 1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J. Biol. Chem. UNITED STATES. 274 (33): 23491–8. doi:10.1074/jbc.274.33.23491. ISSN 0021-9258. PMID 10438528. 

Further reading[edit]