GATA5

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GATA5
Identifiers
Aliases GATA5, GATAS, bB379O24.1, GATA binding protein 5
External IDs MGI: 109497 HomoloGene: 32031 GeneCards: 140628
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080473

NM_008093

RefSeq (protein)

NP_536721.1

NP_032119.2

Location (UCSC) Chr 20: 62.46 – 62.48 Mb Chr 2: 180.33 – 180.33 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene.[3][4]

Function[edit]

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.[4]

Role in development[edit]

Gata5 is a transcription factor. Gata5 regulates the proper development of the heart. Early in embryo development, Gata5 helps in making sure that there are enough heart muscle precursor cells produced to differentiate into the final myocardial cells. It also regulates other genes that are crucial to successful heart development.[5] As pregnancy progresses, Gata 5 is involved in the specification of the heart tissue that becomes the ventricles. Problems can arise when Gata5 is overexpressed. This overexpression can lead to ectopic foci. Ectopic foci are also known as ectopic pacemakers. They are bundles of cells that can cause cardiac pacing that are located in places in the heart where they’re not supposed to be. These cells can become excited before the heart is supposed to be excited. This causes the heart to beat and thus contract before it should. Oftentimes, this is not a big deal and the heart naturally reverts to its normal pacing. However, if it’s caused by problems with development in the heart – if Gata5 did not express properly in the embryo- then this can lead to constant ectopic foci problems. These problems include tachycardia (the heart beating too fast), bradycardia (the heart beating too slow), or ventricular fibrillation[6] which is a serious condition where the ventricles of the heart aren’t pumping consistently and can’t get blood out to the body.

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gao X, Sedgwick T, Shi YB, Evans T (May 1998). "Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation". Molecular and Cellular Biology. 18 (5): 2901–11. doi:10.1128/mcb.18.5.2901. PMC 110669free to read. PMID 9566909. 
  4. ^ a b "Entrez Gene: GATA5 GATA binding protein 5". 
  5. ^ Reiter JF, Alexander J, Rodaway A, Yelon D, Patient R, Holder N, Stainier DY (November 1999). "Gata5 is required for the development of the heart and endoderm in zebrafish". Genes & Development. 13 (22): 2983–95. doi:10.1101/gad.13.22.2983. PMC 317161free to read. PMID 10580005. 
  6. ^ "Ventricular fibrillation". Mayo Clinic. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.