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AliasesZNF598, zinc finger protein 598, HEL2
External IDsOMIM: 617508 MGI: 2670965 HomoloGene: 5672 GeneCards: ZNF598
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ZNF598
Genomic location for ZNF598
Band16p13.3Start1,997,654 bp[1]
End2,009,821 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 16: 2 – 2.01 MbChr 17: 24.67 – 24.68 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Zinc finger protein 598 (ZNF598) is a protein that in humans is encoded by the ZNF598 gene.[5]


Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. ZNF598 and its yeast homologue Hel2 are ubiquitin ligases that ubiquitinate the 40S ribosomal subunit during ribosome-associated protein quality control.[6][7][8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167962 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041130 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger protein 598".
  6. ^ Juszkiewicz S, Hegde RS (February 2017). "Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination". Molecular Cell. 65 (4): 743–750.e4. doi:10.1016/j.molcel.2016.11.039. PMC 5316413. PMID 28065601.
  7. ^ Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ (February 2017). "ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation". Molecular Cell. 65 (4): 751–760.e4. doi:10.1016/j.molcel.2016.12.026. PMC 5321136. PMID 28132843.
  8. ^ Sitron CS, Park JH, Brandman O (May 2017). "Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation". RNA. 23 (5): 798–810. doi:10.1261/rna.060897.117. PMID 28223409.
  9. ^ Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T (July 2017). "Ubiquitination of stalled ribosome triggers ribosome-associated quality control". Nature Communications. 8 (1): 159. doi:10.1038/s41467-017-00188-1. PMID 28757607.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.