Thymidine triphosphate

Thymidine triphosphate
Names
	IUPAC name Thymidine 5′-(tetrahydrogen triphosphate)
	Systematic IUPAC name O1-{[(2R,3S,5R)-5-(2,4-Dioxo-5-methyl-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
	Other names dTTP, 2′-Deoxythymidine triphosphate
Identifiers
CAS Number	365-08-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:18077;
ChEMBL	ChEMBL363559 ;
ChemSpider	58493 =;
ECHA InfoCard	100.006.064
IUPHAR/BPS	5505;
MeSH	thymidine+5'-triphosphate
PubChem CID	64968;
UNII	QOP4K539MU ;
CompTox Dashboard (EPA)	DTXSID30189998 ;
	SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O;
Properties
Chemical formula	C10H17N2O14P3
Molar mass	482.168
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). (what is ?) Infobox references

Thymidine triphosphate (TTP), also called deoxythymidine triphosphate (dTTP),^[1] is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA. Unlike the other deoxyribonucleoside triphosphates, thymidine triphosphate does not always contain the "deoxy" prefix in its name.^[2] This is because dTTP does not have a corresponding ribonucleoside triphosphate, as the uridine triphosphate, which lacks thymidine's 5-methylation, is used instead.

dTTP is synthesized via the methylation of dUMP via thymidylate synthase.

It can be used by DNA ligase to create overlapping "sticky ends" so that protruding ends of opened microbial plasmids may be closed up.

References

^ "Thymidine 5'-triphosphate (PAMDB000346)". University of Maryland, Baltimore. 2018-01-22. Archived from the original on 2023-10-29. Retrieved 2023-10-29.
^ Coghill, Anne M.; Garson, Lorrin R., eds. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.

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[1] "Thymidine 5'-triphosphate (PAMDB000346)". University of Maryland, Baltimore. 2018-01-22. Archived from the original on 2023-10-29. Retrieved 2023-10-29.

[2] Coghill, Anne M.; Garson, Lorrin R., eds. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.

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