Xibornol

Xibornol
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J01XX02 (WHO) ;
Identifiers
	IUPAC name 4,5-dimethyl-2-[(1S,4R,6R)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl]phenol;
CAS Number	13741-18-9 ;
PubChem CID	11777299;
DrugBank	DB13714 ;
ChemSpider	9951982 ;
UNII	RQ12GMY0FZ;
KEGG	D07433 ;
ChEBI	CHEBI:131713 ;
ChEMBL	ChEMBL2104519;
CompTox Dashboard (EPA)	DTXSID60472406 ;
ECHA InfoCard	100.033.906
Chemical and physical data
Formula	C18H26O
Molar mass	258.405 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1cc(c(cc1C2CC3CCC2(C)C3(C)C)C)C;
	InChI InChI=1S/C18H26O/c1-11-8-14(16(19)9-12(11)2)15-10-13-6-7-18(15,5)17(13,3)4/h8-9,13,15,19H,6-7,10H2,1-5H3 ; Key:RNRHMQWZFJXKLZ-UHFFFAOYSA-N ;
	(verify)

Xibornol is a lipophilic substance with antiseptic properties, mainly used in Italy and Spain. It is primarily administered to the throat as a spray mouthwash. As of 2007, all approved forms are water-based suspensions.^[1]

The drug was discovered in the 1970s.^[2]

References

^ Cirri M, Mura P, Mora PC (August 2007). "Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems". International Journal of Pharmaceutics. 340 (1–2): 84–91. doi:10.1016/j.ijpharm.2007.03.021. PMID 17531411.
^ Celandroni F, Mazzantini D, Calvigioni M, Ceccanti S, Vecchiani S, Battaglia S, et al. (2022). "Antimicrobial Activity of Xibornol and a Xibornol-Based Formulation Against Gram-Positive Pathogens of the Respiratory Tract". Advances in Microbiology, Infectious Diseases and Public Health. Advances in Experimental Medicine and Biology. Vol. 1369. pp. 101–106. doi:10.1007/5584_2021_664. hdl:11568/1115592. ISBN 978-3-031-01994-4. PMID 34387849. S2CID 236998271.

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[pmid17531411-1] Cirri M, Mura P, Mora PC (August 2007). "Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems". International Journal of Pharmaceutics. 340 (1–2): 84–91. doi:10.1016/j.ijpharm.2007.03.021. PMID 17531411.

[2] Celandroni F, Mazzantini D, Calvigioni M, Ceccanti S, Vecchiani S, Battaglia S, et al. (2022). "Antimicrobial Activity of Xibornol and a Xibornol-Based Formulation Against Gram-Positive Pathogens of the Respiratory Tract". Advances in Microbiology, Infectious Diseases and Public Health. Advances in Experimental Medicine and Biology. Vol. 1369. pp. 101–106. doi:10.1007/5584_2021_664. hdl:11568/1115592. ISBN 978-3-031-01994-4. PMID 34387849. S2CID 236998271.

[1]

[2]

v t e Antibacterials: others (J01X, D06AX)
Glycopeptides Lipoglycopeptides	Avoparcin Corbomycin Dalbavancin Oritavancin Ristocetin Teicoplanin Telavancin Vancomycin
Polymyxins	Colistin Polymyxin B
Steroid antibacterials	Fusidic acid
Imidazole derivatives	Metronidazole Ornidazole Tinidazole
Pleuromutilins	Azamulin Lefamulin Retapamulin Tiamulin Valnemulin
Nitrofuran derivatives	Furazolidone Nifuroxazide Nifurtoinol Nifurzide Nitrofurantoin Nitrofurazone
Other antibacterials	Bacitracin Clofoctol Daptomycin Fosfomycin Furaltadone Lefamulin Linezolid Mandelic acid Methenamine Nitroxoline Novobiocin Spectinomycin Tedizolid Xibornol