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ECHA InfoCard100.012.293 Edit this at Wikidata
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Molar mass275.2 g/mol g·mol−1
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Nifuroxazide (INN) is an oral nitrofuran antibiotic, patented since 1966[1] and used to treat colitis and diarrhoea in humans and non-humans.[2] It is sold under the brand names Ambatrol, Antinal, Bacifurane, Diafuryl (Turkey), Pérabacticel (France), Antinal, Diax (Egypt), Nifrozid, Ercefuryl (Romania, Czech Republic, Russia), Erfuzide (Thailand), Endiex (Slovakia), Enterofuryl (Russia), Pentofuryl (Germany), Topron, Enterovid (Latin America), Eskapar (Mexico), Enterocolin,TERRACOLIN 100Mg./200Mg.(Bolivia), Apazid (Morocco), Nifural (Indonesia) and Septidiaryl. It is sold in capsule form and also as a suspension. A 2016 clinical trial showed Nifuroxazide to be more effective compared to probiotics in treating acute diarrhea in adults.[3]


Maurice Claude Ernest Carron patented the drug in the United States in 1966.[1] Subsequent patents issued to Germano Cagliero of Marxer S.p.A describe the use of nifuroxazide as an antibiotic used to treat livestock.[2]

Effectiveness in humans[edit]

In 1997, in an Ivory Coast promotional leaflet, GlaxoSmithKline claimed that nifuroxazide (under the brand name "Ambatrol") is an anti-dehydration treatment, "neutralise[s] microbacterials" in diarrhoea, and has "a spectrum which covers most enteropathogenic microbacterials, Shigella, Escherichia coli, Salmonella, Staphylococci, Klebsiella, Yersinia".[4] The international non-profit organization Healthy Skepticism, at the time using their former name, Medical Lobby for Appropriate Marketing (MaLAM), disagreed, stating "We have not found any scientific evidence to support these claims."[4] A 2016 clinical trial showed Nifuroxazide to treat diarrhea in an average of 2 days compared to 5 days with probiotics.[3]


  1. ^ a b USPTO No. 3290213 |
  2. ^ a b USPTO No 4093746 |
  3. ^ a b Begovic, B.; Ahmedtagic, S.; Calkic, L.; Vehabović, M.; Kovacevic, S. B.; Catic, T.; Mehic, M. (2016). "Open Clinical Trial on Using Nifuroxazide Compared to Probiotics in Treating Acute Diarrhoeas in Adults". Materia Socio-Medica. 28 (6): 454–458. doi:10.5455/msm.2016.28.454-458. PMC 5239654. PMID 28144199.
  4. ^ a b "SmithKline Beecham Ambatrol (nifuroxazide)". Healthy Skepticism. June 1997. Archived from the original on 2010-12-21. Retrieved 2010-12-21.

External links[edit]