N-substituted formamide deformylase: Difference between revisions
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:''N''-benzylformamide + H<sub>2</sub>O <math>\rightleftharpoons</math> formate + benzylamine |
:''N''-benzylformamide + H<sub>2</sub>O <math>\rightleftharpoons</math> formate + benzylamine |
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[N-benzylformamide|''N''-benzylformamide]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[formate]] and [[benzylamine]].<ref>{{cite journal | vauthors = Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M | title = Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 38 | pages = 13726–31 | date = September 2004 | pmid = 15358859 | pmc = 518824 | doi = 10.1073/pnas.0405082101 }}</ref> |
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[N-benzylformamide|''N''-benzylformamide]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[formate]] and [[benzylamine]].<ref>{{cite journal | vauthors = Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M | title = Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 38 | pages = 13726–31 | date = September 2004 | pmid = 15358859 | pmc = 518824 | doi = 10.1073/pnas.0405082101 | bibcode = 2004PNAS..10113726F | doi-access = free }}</ref> |
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This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The [[List of enzymes|systematic name]] of this enzyme class is '''''N''-benzylformamide amidohydrolase''' and is also called '''NfdA'''. The enzyme is produced by ''[[Arthrobacter pascens]]'' bacteria.<ref>{{cite book| chapter-url = https://books.google.com/books?id=hN38HsVK5HgC&pg=PA376 |
This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The [[List of enzymes|systematic name]] of this enzyme class is '''''N''-benzylformamide amidohydrolase''' and is also called '''NfdA'''. The enzyme is produced by ''[[Arthrobacter pascens]]'' bacteria.<ref>{{cite book| chapter-url = https://books.google.com/books?id=hN38HsVK5HgC&q=benzylformamide&pg=PA376|chapter = 3.5.1.91 ''N''-substituted formamide deformylase|pages = 376–378|title = Class 3 Hydrolases: EC 3.4.22-3.13|series = Springer Handbook of Enzymes|editor1-first = D.|editor1-last = Schomburg|editor2-first = I.|editor2-last = Schomburg|editor3-last = Chang|editor3-first = A. | name-list-style = vanc |edition = 2nd|publisher = [[Springer Science & Business Media]]|year = 2009|isbn = 9783540857051}}</ref> |
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== References == |
== References == |
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Revision as of 02:12, 11 September 2021
| N-substituted formamide deformylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.1.91 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a N-substituted formamide deformylase (EC 3.5.1.91) is an enzyme that catalyzes the chemical reaction
- N-benzylformamide + H2O formate + benzylamine
Thus, the two substrates of this enzyme are N-benzylformamide and H2O, whereas its two products are formate and benzylamine.[1]
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-benzylformamide amidohydrolase and is also called NfdA. The enzyme is produced by Arthrobacter pascens bacteria.[2]
References
- ^ Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M (September 2004). "Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning". Proceedings of the National Academy of Sciences of the United States of America. 101 (38): 13726–31. Bibcode:2004PNAS..10113726F. doi:10.1073/pnas.0405082101. PMC 518824. PMID 15358859.
- ^ Schomburg D, Schomburg I, Chang A, eds. (2009). "3.5.1.91 N-substituted formamide deformylase". Class 3 Hydrolases: EC 3.4.22-3.13. Springer Handbook of Enzymes (2nd ed.). Springer Science & Business Media. pp. 376–378. ISBN 9783540857051.
