Agmatinase

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agmatinase
Identifiers
EC number 3.5.3.11
CAS number 37289-16-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an agmatinase (EC 3.5.3.11) is an enzyme that catalyzes the chemical reaction

agmatine + H2O \rightleftharpoons putrescine + urea

Thus, the two substrates of this enzyme are agmatine and H2O, whereas its two products are putrescine and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase, and SpeB. This enzyme participates in urea cycle and metabolism of amino groups.

Genetics[edit]

Agmatine ureohydrolase (agmatinase)
Identifiers
Symbols AGMAT ; FLJ23384
External IDs MGI1923236 HomoloGene99855 GeneCards: AGMAT Gene
EC number 3.5.3.11
RNA expression pattern
PBB GE AGMAT 221648 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79814 75986
Ensembl ENSG00000116771 ENSMUSG00000040706
UniProt Q9BSE5 A2AS89
RefSeq (mRNA) NM_024758 NM_001081408
RefSeq (protein) NP_079034 NP_001074877
Location (UCSC) Chr 1:
15.9 – 15.91 Mb
Chr 4:
141.75 – 141.76 Mb
PubMed search [1] [2]

In humans, the enzyme is encoded by the AGMAT gene.[1][2][3][4]

Structural studies[edit]

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GQ6, 1GQ7, 1WOG, 1WOH, and 1WOI.

Inhibitors[edit]

References[edit]

  1. ^ Mistry SK, Burwell TJ, Chambers RM, Rudolph-Owen L, Spaltmann F, Cook WJ, Morris SM Jr (Jan 2002). "Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus". Am J Physiol Gastrointest Liver Physiol 282 (2): G375–81. doi:10.1152/ajpgi.00386.2001. PMID 11804860. 
  2. ^ Dallmann K, Junker H, Balabanov S, Zimmermann U, Giebel J, Walther R (Dec 2003). "Human agmatinase is diminished in the clear cell type of renal cell carcinoma". Int J Cancer 108 (3): 342–7. doi:10.1002/ijc.11459. PMID 14648699. 
  3. ^ Iyer RK, Kim HK, Tsoa RW, Grody WW, Cederbaum SD (Mar 2002). "Cloning and characterization of human agmatinase". Mol Genet Metab 75 (3): 209–18. doi:10.1006/mgme.2001.3277. PMID 11914032. 
  4. ^ "Entrez Gene: AGMAT agmatine ureohydrolase (agmatinase)".