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Activation-induced cytidine deaminase
Symbols AICDA ; AID; ARP2; CDA2; HEL-S-284; HIGM2
External IDs OMIM605257 MGI1342279 HomoloGene7623 GeneCards: AICDA Gene
EC number
RNA expression pattern
PBB GE AICDA 219841 at tn.png
More reference expression data
Species Human Mouse
Entrez 57379 11628
Ensembl ENSG00000111732 ENSMUSG00000040627
UniProt Q9GZX7 Q9WVE0
RefSeq (mRNA) NM_020661 NM_009645
RefSeq (protein) NP_065712 NP_033775
Location (UCSC) Chr 12:
8.75 – 8.77 Mb
Chr 6:
122.55 – 122.56 Mb
PubMed search [1] [2]

Activation-induced cytidine deaminase, also known as AICDA and AID, is an enzyme which in humans is encoded by the AICDA gene.[1]


This gene encodes a DNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes.[1]

Recently, AICDA has been implicated in active DNA demethylation. AICDA can deaminate 5-methylcytosine, which can then be replaced with cytosine by base excision repair.[2]

Clinical significance[edit]

Defects in this gene are associated with Hyper-IgM syndrome type 2.

See also[edit]


  1. ^ a b "Entrez Gene: AICDA activation-induced cytidine deaminase". 
  2. ^ Morgan HD, Dean W, Coker HA, Reik W, Petersen-Mahrt SK (2004). "Activation-induced Cytidine Deaminase Deaminates 5-Methylcytosine in DNA and Is Expressed in Pluripotent Tissues". JBC 279 (50): 52353–52360. doi:10.1074/jbc.M407695200. 

Further reading[edit]

External links[edit]