Desquamative interstitial pneumonia: Difference between revisions
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'''Desquamative interstitial pneumonia''' (DIP) is a form of [[idiopathic interstitial pneumonia]] featuring elevated numbers of [[macrophages]] within the alveoli (air sacs) of the lung. The alveolar macrophages have a characteristic light brown pigmentation and accumulate in the alveolar lumen and septa regions of the lower lobes of the lungs<ref>{{Cite journal|last=Diken|first=Özlem Erçen|last2=Şengül|first2=Aysun|last3=Beyan|first3=Ayşe Coşkun|last4=Ayten|first4=Ömer|last5=Mutlu|first5=Levent Cem|last6=Okutan|first6=Oğuzhan|date=2019-1|title=Desquamative interstitial pneumonia: Risk factors, laboratory and bronchoalveolar lavage findings, radiological and histopathological examination, clinical features, treatment and prognosis|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307411/|journal=Experimental and Therapeutic Medicine|volume=17|issue=1|pages=587–595|doi=10.3892/etm.2018.7030|issn=1792-0981|pmc=6307411|pmid=30651839}}</ref>. The typical effects of the macrophage accumulation are inflammation and later fibrosis (thickening and stiffness) of the lung tissue<ref>{{Citation|last=Chakraborty|first=Rebanta K.|title=Desquamative Interstitial Pneumonia|date=2020|url=http://www.ncbi.nlm.nih.gov/books/NBK526079/|work=StatPearls|place=Treasure Island (FL)|publisher=StatPearls Publishing|pmid=30252335|access-date=2020-12-02|last2=Basit|first2=Hajira|last3=Sharma|first3=Sandeep}}</ref>. |
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'''Desquamative interstitial pneumonia''' (DIP) is a form of [[idiopathic interstitial pneumonia]] featuring elevated numbers of [[macrophages]] within the alveoli (air sacs) of the lung. |
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The term DIP is a misnomer.<ref name="pmid32843423">{{cite journal |vauthors=Mukhopadhyay S, Aesif SW, Sansano I|title=5 simple reasons to discard DIP, or why we should stop calling dolphins big fish|journal=J Clin Pathol |pmid=32843423 |doi=10.1136/jclinpath-2020-206669}}</ref> Its name is derived from the former belief that these macrophages were [[pneumocyte]]s that had desquamated.<ref name="isbn0-7216-0187-1">{{cite book |author=Cotran, Ramzi S. |author2=Kumar, Vinay |author3=Fausto, Nelson |author4=Nelso Fausto |author5=Robbins, Stanley L. |author6=Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=740 |isbn=0-7216-0187-1 |oclc= |doi= |accessdate=}}</ref> |
The term DIP is a misnomer.<ref name="pmid32843423">{{cite journal |vauthors=Mukhopadhyay S, Aesif SW, Sansano I|title=5 simple reasons to discard DIP, or why we should stop calling dolphins big fish|journal=J Clin Pathol |pmid=32843423 |doi=10.1136/jclinpath-2020-206669}}</ref> Its name is derived from the former belief that these macrophages were [[pneumocyte]]s that had desquamated.<ref name="isbn0-7216-0187-1">{{cite book |author=Cotran, Ramzi S. |author2=Kumar, Vinay |author3=Fausto, Nelson |author4=Nelso Fausto |author5=Robbins, Stanley L. |author6=Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=740 |isbn=0-7216-0187-1 |oclc= |doi= |accessdate=}}</ref> |
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Revision as of 20:10, 2 December 2020
| Desquamative interstitial pneumonia | |
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| Specialty | Pulmonology  |
Desquamative interstitial pneumonia (DIP) is a form of idiopathic interstitial pneumonia featuring elevated numbers of macrophages within the alveoli (air sacs) of the lung. The alveolar macrophages have a characteristic light brown pigmentation and accumulate in the alveolar lumen and septa regions of the lower lobes of the lungs[1]. The typical effects of the macrophage accumulation are inflammation and later fibrosis (thickening and stiffness) of the lung tissue[2].
The term DIP is a misnomer.[3] Its name is derived from the former belief that these macrophages were pneumocytes that had desquamated.[4]
It is associated with patients with a history of smoking.[5] Since more than 80% of cases occur in smokers, it has been suggested that the term DIP should be discarded and the subset occurring in smokers should be replaced with more accurate terms such as smoking-related interstitial fibrosis (SRIF).[3]
Treatment with methylprednisolone has been reported.[6]
References
- ^ Diken, Özlem Erçen; Şengül, Aysun; Beyan, Ayşe Coşkun; Ayten, Ömer; Mutlu, Levent Cem; Okutan, Oğuzhan (2019-1). "Desquamative interstitial pneumonia: Risk factors, laboratory and bronchoalveolar lavage findings, radiological and histopathological examination, clinical features, treatment and prognosis". Experimental and Therapeutic Medicine. 17 (1): 587–595. doi:10.3892/etm.2018.7030. ISSN 1792-0981. PMC 6307411. PMID 30651839.
{{cite journal}}: Check date values in:|date=(help) - ^ Chakraborty, Rebanta K.; Basit, Hajira; Sharma, Sandeep (2020), "Desquamative Interstitial Pneumonia", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 30252335, retrieved 2020-12-02
- ^ a b Mukhopadhyay S, Aesif SW, Sansano I. "5 simple reasons to discard DIP, or why we should stop calling dolphins big fish". J Clin Pathol. doi:10.1136/jclinpath-2020-206669. PMID 32843423.
- ^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 740. ISBN 0-7216-0187-1.
- ^ Heyneman LE, Ward S, Lynch DA, Remy-Jardin M, Johkoh T, Müller NL (December 1999). "Respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process?". AJR Am J Roentgenol. 173 (6): 1617–22. doi:10.2214/ajr.173.6.10584810. PMID 10584810.
- ^ Paul K, Klettke U, Moldenhauer J, et al. (December 1999). "Increasing dose of methylprednisolone pulse therapy treats desquamative interstitial pneumonia in a child". Eur. Respir. J. 14 (6): 1429–32. doi:10.1183/09031936.99.14614299. PMID 10624777.
External links
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