Restrictive lung disease

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Restrictive lung disease
Classification and external resources
ICD-9 518.89
eMedicine med/2012

Restrictive lung diseases (or restrictive ventilatory defects[1]) are a category of extrapulmonary, pleural, or parenchymal respiratory diseases that restrict lung expansion,[2] resulting in a decreased lung volume, an increased work of breathing, and inadequate ventilation and/or oxygenation. Pulmonary function test demonstrates a decrease in the forced vital capacity.

Pathophysiology[edit]

In disorders that are intrinsic to the lung parenchyma, the underlying process is usually pulmonary fibrosis (scarring of the lung).[3] As the disease progresses, the normal lung tissue is gradually replaced by scar tissue interspersed with pockets of air. This can lead to parts of the lung having a honeycomb-like appearance.

Presentation[edit]

The main symptoms are shortness of breath and cough.[citation needed]

Diagnosis[edit]

In restrictive lung disease, both forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) are reduced, however, the decline in FVC is more than that of FEV1, resulting in a higher than 80% FEV1/FVC ratio. In obstructive lung disease however, FEV1 is reduced while FVC remains stable, consequentially depicting a lower FEV1/FVC ratio.[citation needed]

One definition requires a total lung capacity which is 80% or less of the expected value.[4]

Causes and classification[edit]

Restrictive lung diseases may be due to specific causes which can be intrinsic to the parenchyma of the lung, or extrinsic to it.[5]

Intrinsic[edit]

Many cases of restrictive lung disease are idiopathic (have no known cause). Still, there is generally pulmonary fibrosis.[3] Examples are:

Conditions specifically affecting the interstitium are called interstitial lung diseases.

Extrinsic[edit]

See also[edit]

References[edit]

  1. ^ Johns Hopkins School of Medicine's Interactive Respiratory Physiology > Restrictive Ventilatory Defect Retrieved on February 25, 2010
  2. ^ Sharma, Sat. "Restrictive Lung Disease". Retrieved 2008-04-19. 
  3. ^ a b PULMONARY FUNCTION TESTS A Workshop on Simple Spirometry & Flow Volume Loops. Dr. S. Osborne, Dept. Cellular & Physiological Sciences. Mars 2009
  4. ^ Brack T, Jubran A, Tobin MJ (May 2002). "Dyspnea and decreased variability of breathing in patients with restrictive lung disease". Am. J. Respir. Crit. Care Med. 165 (9): 1260–4. doi:10.1164/rccm.2201018. PMID 11991875. 
  5. ^ "eMedicine - Restrictive Lung Disease : Article by Sat Sharma". Retrieved 2008-11-21. 
  6. ^ Walker J, Cooney M, Norton S (August 1989). "Improved pulmonary function in chronic quadriplegics after pulmonary therapy and arm ergometry". Paraplegia 27 (4): 278–83. doi:10.1038/sc.1989.42. PMID 2780083. 
  7. ^ eMedicine Specialties > Pulmonology > Interstitial Lung Diseases > Restrictive Lung Disease Author: Lalit K Kanaparthi, MD, Klaus-Dieter Lessnau, MD, Sat Sharma, MD. Updated: Jul 27, 2009
  8. ^ eMedicine Specialties > Pulmonology > Interstitial Lung Diseases > Restrictive Lung Disease Author: Lalit K Kanaparthi, MD, Klaus-Dieter Lessnau, MD, Sat Sharma, MD. Updated: Jul 27, 2009