Non-specific interstitial pneumonia

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Non-specific interstitial pneumonia (NSIP) is a form of idiopathic interstitial pneumonia.[1][2][3]

Patients with an NSIP histologic pattern on biopsy have a better prognosis than those with usual interstitial pneumonia (UIP). There are two variants of NSIP: cellular and fibrosing. The cellular variant features chronic inflammatory cells with minimal collagen deposition while the fibrosing pattern consists of diffuse interstitial fibrosis with fewer inflammatory cells. In contrast to UIP, NSIP has little or no honeycomb change, and fibroblast foci are scant or absent.[4][5]


  1. ^ "Idiopathic Interstitial Pneumonias: Interstitial Lung Diseases: Merck Manual Professional". Retrieved 2008-12-09. 
  2. ^ Katzenstein AL, Fiorelli RF (February 1994). "Nonspecific interstitial pneumonia/fibrosis. Histologic features and clinical significance". Am. J. Surg. Pathol. 18 (2): 136–47. doi:10.1097/00000478-199402000-00003. PMID 8291652. 
  3. ^ Martinez FJ (2006). "Idiopathic interstitial pneumonias: usual interstitial pneumonia versus nonspecific interstitial pneumonia". Proc Am Thorac Soc 3 (1): 81–95. doi:10.1513/pats.200511-123JH. PMID 16493155. 
  4. ^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 731. ISBN 0-7216-0187-1. 
  5. ^ Leslie KO (November 2005). "Historical perspective: a pathologic approach to the classification of idiopathic interstitial pneumonias". Chest 128 (5 Suppl 1): 513S–519S. doi:10.1378/chest.128.5_suppl_1.513S. PMID 16304241.