1,2-dihydrovomilenine reductase

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1,2-dihydrovomilenine reductase
Identifiers
EC number 1.3.1.73
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 1,2-dihydrovomilenine reductase (EC 1.3.1.73) is an enzyme that catalyzes the chemical reaction

17-O-acetylnorajmaline + NADP+ \rightleftharpoons 1,2-dihydrovomilenine + NADPH + H+

Thus, the two substrates of this enzyme are 17-O-acetylnorajmaline and NADP+, whereas its 3 products are 1,2-dihydrovomilenine, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 17-O-acetylnorajmaline:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

References[edit]

  • Gao S, von Schumann G, Stockigt J (2002). "A newly-detected reductase from Rauvolfia closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline". Planta. Med. 68 (10): 906–11. doi:10.1055/s-2002-34935. PMID 12391554.